【摘要】 目的:研究染色体9p21.3区的单核苷酸多态性(single nucleotide polymorphism,SNP)与汉族人群中慢性牙周炎的相关性。方法:应用TaqMan荧光实时定量PCR方法,对172例牙周正常者和221例中度以上慢性牙周炎患者的rs2891168、rs1333048和rs1333042 3个单核苷酸多态性位点进行分析。采用SPSS16.0软件包对数据进行χ2检验。结果:rs2891168与慢性牙周炎存在显著性关联(P=0.003),病例组中,等位基因G的频率显著高于对照组(OR=1.209,95%CI:1.001～1.461,P=0.045),而rs1333048、rs1333042基因型与等位基因频率在牙周正常组和慢性牙周炎组间的分布差异均不显著。结论:染色体9p21.3区存在与慢性牙周炎关联的SNP,显示该区域可能是慢性牙周炎易感区域,但其作用机制有待进一步研究。更多还原

【Abstract】 PURPOSE:To investigate the association of the single nucleotide polymorphism(SNP) in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population.METHODS: rs2891168,rs1333048 and rs1333042 genotypes of randomly grouped 172 healthy control subjects and 221 patients with chronic periodontitis(CP) were genotyped by TaqMan probe real-time fluorescent quantitative PCR.Statistical analysis of Chi-square test was performed using SPSS16.0 software package.RESULTS: Rs2891168 was closely associated with chronic periodontitis(P=0.003),and the frequency of G allele was higher in the patients compared with the control(48.36% vs 40.00%,OR=1.209,95% CI: 1.001-1.461,P=0.045).Rs1333048 and rs1333042 were not associated with chronic periodontitis.CONCLUSIONS: There is SNP correlated with chronic periodontitis in chromosome 9p21.3,which indicates that the 9p21.3 locus may be the susceptible region.However,the mechanism remains unclear.更多还原