【摘要】 目的探讨白癜风患者焦虑情绪与血清β-内啡肽水平的关系。方法选择80例进展期白癜风患者(病例组)和40例健康体检者(对照组)为研究对象,采用ZUNG焦虑自评量表(SAS)进行焦虑情绪评分,应用酶联免疫吸附法(ELISA)测定血清β-内啡肽水平。结果病例组SAS评分(50.85±12.23)显著高于对照组(37.86±11.23)(t=5.63,P<0.01)。病例组焦虑发生率(47.5%,38/80)显著高于对照组(5.0%,2/40)(χ2=21.67,P<0.01)。在病例组中,对于SAS评分和焦虑发生率,女性患者高于男性患者,未婚患者高于已婚患者,皮肤损伤发生于暴露部位的患者高于发生于非暴露部位的患者,16～24岁的患者高于25岁以上的患者,差异均有统计学意义(P<0.05或P<0.01);病程≤6个月的患者与病程>6个月的患者SAS评分和焦虑发生率比较,有高等学历的患者与无高等学历的患者SAS评分和焦虑发生率比较,差异均无统计学意义(P>0.05)。病例组患者血清β-内啡肽质量浓度为(219.11±30.18)ng/L,显著高于对照组[(162.16±19.65)ng/L](t=9.12,P<0.01)。病例组中,有焦虑症状的患者血清β-内啡肽质量浓度为(241.71±31.76)ng/L,显著高于无焦虑症状的患者[(197.91±23.29)ng/L](t=8.66,P<0.01)。结论白癜风患者可能存在焦虑情绪,且患者血清中β-内啡肽水平可能与白癜风及焦虑情绪有关。更多还原

【Abstract】 Objective To investigate the relationship between anxiety and serum β-endorphin in patients with vitiligo.Methods Eighty patients with developing vitiligo(case group) and 40 healthy controls(control group) were selected.ZUNG self-rating anxiety scale(SAS) was employed to determine the anxiety status,and enzyme linked immunosorbent assay(ELISA) was adopted to measure the serum β-endorphin levels.Results The SAS scores in case group(50.85±12.23)was significantly higher than that in control group(37.86±11.23)(t=5.63,P<0.01).The prevalence of anxiety in case group(47.5%,38/80) was significantly higher than that in control group(5.0%,2/40)(χ2 =21.67,P<0.01).In case group,the SAS score and prevalence of anxiety of females were significantly higher than those of males;the SAS score and prevalence of anxiety of the unmarried were significantly higher than those of the married;the SAS score and prevalence of anxiety in patients with vitiligo in exposed skin were significantly higher than those in non-exposed skin;and the SAS score and prevalence of anxiety in patients aged between 16 and 24 were significantly higher than those aged more than 25(P<0.05 or P<0.01).There was no significant difference in SAS score and prevalence of anxiety between patients with disease duration ≤6 months and those with disease duration >6 months and between patients with higher education and those without higher education(P>0.05).The mass concentration of serum β-endorphin in case group was(219.11±30.18)ng/L,which was significantly higher than that in control group[(162.16±19.65)ng/L](t=9.12,P<0.01).In case group,the mass concentration of serum β-endorphin in patients with anxiety was(241.71±31.76)ng/L,which was significantly higher than that in patients without anxiety [(197.91±23.29)ng/L](t=8.66,P<0.01).Conclusion Patients with vitiligo may be affected by anxiety,and the serum β-endorphin levels may be associated with vitiligo and anxiety.更多还原