【摘要】 目的探讨腹膜透析患者血清心肌肌钙蛋白T(cTnT)对其心脑血管疾病及死亡的预测价值。方法选择衡阳市第一人民医院行规律腹膜透析患者214例,检测透析前后生化及心脏形态改变。随访3 a或至其死亡,记录随访期间患者死亡及发生心脑血管事件情况。结果 cTnT与糖尿病、心脑血管病史、hs-CRP、左心室重量指数(LVMI)呈正相关,与eGFR、左室射血分数呈负相关。生存分析显示cTnT≥0.1μg/L组初发心脑血管事件、心脑血管事件死亡率及全因死亡率明显升高;COX比例风险回归模型分析示cTnT可预测初发心脑血管事件、心脑血管事件死亡率及全因死亡率,并独立于hs-CRP、eGFR、LVMI、左室射血分数、透析时间因素之外。结论 cTnT为腹膜透析患者初发心脑血管事件、心脑血管病死亡事件及全因死亡事件的独立预测因子。更多还原

【Abstract】 Objective To investigate whether cardiac troponin T(cTnT) independently predicts outcome in chronic peritoneal dialysis(PD) with end-stage renal disease.Methods Baseline cTnT,echocardiography and biochemical characteristics were assessed in 214 chronic PD patients who were followed prospectively for 3 years or until death.Results Increased cTnT correlated significantly with history of diabetes and cardiovascular events(CVE),increase of high-sensitivity CRP and left ventricular mass index(LVMI),decrease of eGFR and left ventricular ejection fraction.Kaplan-Meier survival curve analysis revealed cTnT≥0.1 μg/L was linked to fatal and nonfatal CVE,all-cause mortality and cardiovascular death.Multivariable COX regression analysis indicated cTnT was independently predictive of fatal and nonfatal CVEs,all-cause mortality,cardiovascular death.Conclusion cTnT is an independent predictor of long term mortality,cardiovascular death and events in PD patients.更多还原