【摘要】 目的探讨缺氧诱导因子-1α(HIF-1α)在胃癌组织中的表达及其意义。方法选择120例胃癌标本(胃癌组)、68例正常胃黏膜组织(对照组),采用SP法检测两组HIF-1α的表达,并分析HIF-1α的表达与临床病理特征的关系。结果胃癌组HIF-1α阳性表达率为70.83%,对照组不表达,两组比较P<0.01。胃癌组中不同肿瘤分期、分化程度、浸润深度、淋巴结转移间HIF-1α阳性表达率差异均有统计学意义(P均<0.01)。结论 HIF-1α可作为评估胃癌发展、转移及预后的参考指标。更多还原

【Abstract】 Objective To evaluate the expression of HIF-1α in gastric cancer,and explore its correlation to clinical features of gastric cancer.Methods The expression of HIF-1α in 120 specimens of gastric cancer and 68 no gastric cancer as control were detected by SP immunohis to chemistry.The correlations of HIF-1α to clinico pathologic features were analyzed.Results Of the 120 specimens,85 cases(70.83%) were HIF-1α positive,while there were no expression rate in control group.The positive rate of HIF-1α was significantly lower in stageⅠ+Ⅱ patients than that in stage Ⅲ+Ⅳ patients(52.08% vs 83.33%,P<0.01),significantly lower in T1+T2 patients than in T3+T4 patients(51.28% vs 80.25%,P<0.01),significantly lower in moderate or high differentiation patients than in poor differentiation patients(44.74% vs 82.93%,P<0.01),significantly lower in negative of lymphnode metastasis patients than in positive patients(57.41% vs 81.82%,P<0.01),and significantly lower in the patients without distant metastasis than in the patients with distant metastasis(58.57% vs 88.00%,P<0.01).Conclusions HIF-1α can be used as the assessment of gastric cancer development,metastasis and proghosis.更多还原