【摘要】 目的研究125I粒子植入对兔VX2肝移植瘤的疗效,观察其对周围正常肝组织的影响。方法 12只新西兰大白兔VX2肝肿瘤模型随机平均分为对照组和治疗组,治疗组植入125I粒子,对照组植入空心粒子,在粒子植入前,植入后7、14、28、60 d行CT增强扫描及肝功能检查,并在第60天做组织学观察。结果治疗组植入后7、14、28、60 d肿瘤体积较对照组均缩小,治疗后14 d治疗组ALT较对照组降低,治疗后7、14 d AST较对照组降低。治疗组60 d内CT增强扫描未监测到肿瘤周围肝组织出现放射性肝损伤。结论125I粒子植入治疗兔移植性肝肿瘤,可有效抑制肿瘤生长,改善肝功能,对周围正常肝组织的放射性损伤较轻,是一种安全、有效的治疗方法。更多还原

【Abstract】 Objective To evaluate the therapeutic effect of 125Iodine seeds on the rabbit VX2 model and to examine changes in tissues of hepatoma and normal liver.Methods Twelve VX2 model animals made from New Zealand rabbits were divided into two groups,the therapy group and the control group.125Iodine seeds and dummy seeds were implanted into the tumors.CT-enhanced scanning and hepatic function examination were performed before the implantation and at 7,14,28 and 60 d after implantation.Pathological study of tumor and normal liver was done to evaluate the damage caused by 125I seeds.Results The tumors in the therapy group were smaller than in the control group at 7,14,28,and 60 d after implantation.In the therapy group,the ALT value was decreased after 14 d,and the AST value was decreased after 7 and 14 d after implantation,as compared to those in the control group.Radiation injury was not detected with CT in the therapy group over the period of 60 d.Conclusion Brachytherapy with 125I seeds can significantly inhibit tumor growth while retaining liver function;hence it is a safe and effective technique.更多还原