【摘要】 目的探讨喹硫平与齐拉西酮合并艾司西酞普兰治疗难治性抑郁症的疗效与副反应。方法将62例难治性抑郁症患者分为喹硫平组31例和齐拉西酮组31例,两组同时服用艾司西酞普兰,观察8周。于疗前和治疗2、4、6及8周末采用汉密尔顿抑郁量表(HAMD-17)评定疗效,用副反应量表(TESS)评定不良反应。结果两组均有显著疗效(P<0.05,P<0.01),但两组有效率比较无显著性差异(P>0.05)。喹硫平组嗜睡副作用明显多于齐拉西酮组,两组比较有显著性差异(P<0.05)。结论喹硫平或齐拉西酮合并艾司西酞普兰治疗难治性抑郁症疗效好,起效快,齐拉西酮不良反应少。更多还原

【Abstract】 Objective To explore the efficacy and side effects of escitalopram combined with quetiapine or ziprasidone in treating refractory depression.Methods 62 patients with refractory depression were divided into quetiapine group(n=31) and ziprasidone group(n=31) with basic treatment of escitalopram and were followed up for 8 weeks.The efficacy and side effects were evaluated with Hamilton depressive scale(HAMD-17) and treatment emergent symptom scale(TESS) at the baseline and at the 2nd,4th,6th and 8th weekend of the treatment.Results Both quetiapine group and ziprasidone group showed good efficacy(P<0.05,P<0.01).But there was no significant difference between the two groups(P>0.05).Compared with ziprasidone group,there were more patients in quetiapine group experienced lethargy(P<0.05).Conclusion Escitalopram combined with quetiapine or ziprasidone have good and rapid efficacy in treating refractory depression.Ziprasidone has fewer side effects compared with quetiapine in the adjunctive therapy of refractory depression.更多还原