【摘要】 目的:探讨热疗联合腹腔灌注化疗治疗恶性腹腔积液的临床疗效和不良反应。方法:将恶性腹腔积液患者58例分为两组,腹腔灌注化疗同时配合热疗组(治疗组)30例,单纯腹腔灌注化疗组(对照组)28例。评估疗效及不良反应。结果:腹腔积液疗效评价:治疗组有效率为86.7%(26/30),对照组有效率57.2%(16/28),两组差异有统计学意义(P=0.012);生活质量评价:治疗组改善96.7%(29/30),对照组改善71.4%(20/28),两组差异有统计学意义(P=0.008)。两组的不良反应发生率差异无统计学意义(P>0.05)。结论:热疗加局部腹腔灌注化疗治疗恶性腹腔积液疗效肯定,不良反应轻微,值得临床推广。更多还原

【Abstract】 Objective:To investigate the clinical efficacy and adverse reactions of hyperthermia combined with intraperitoneal chemotherapy in the reatment of malignant ascites.Methods:Fifty-eight patients with malignant ascites were divided into two groups; 30 patients in intraperitoneal chemotherapy combined with hyperthermia group(treatment group) and 28 patients in intraperitoneal chemotherapy group(control group).The efficacy and adverse reactions were assessed.Results:Clinical evaluation of ascites:the efficacy was 86.7%(26/30) in the treatment group and 57.2%(16/28) in the control group with statistical difference(P =0.012).The quality of Life was improved up to 96.7%(29/30) in the treatment group,while 71.4%(20/28) in the control with significant difference (P =0.008).No significant difference was observed of the adverse reactions between the two groups(P > 0.05 ).Conclusion: Intraperitoneal chemotherapy combined with local hyperthermia for the treatment of malignant ascites is effective with mild adverse reactions. It is worthy of clinical promotion.更多还原