【摘要】 目的探讨伏立康唑治疗侵袭性真菌感染的疗效、安全性以及降低医疗成本的方法。方法回顾性分析43例血液系统疾病合并侵袭性真菌感染患者,根据不同的抗真菌治疗方案分为两组,方案1组给予静脉伏立康唑治疗,首日负荷剂量0.4g/次,1次/12h,而后维持剂量0.2g/次,1次/12h,体温正常1～2星期后改为口服伏立康唑片,0.2g/次,1次/12h,维持治疗。方案2组给予口服伏立康唑片治疗,首日负荷剂量0.4g/次,1次/12h,而后维持剂量0.2g/次,1次/12h。结果 43例患者中4例出现转氨酶一过性升高,2例出现视觉障碍,2例出现皮疹,无心律失常,无肾功能损伤,无水肿等不良反应。方案1组和方案2组抗真菌有效率分别为79.2%和63.2%,抗真菌治愈率分别为54.2%和42.1%,检验结果均显示P>0.20,可认为两组间抗真菌有效率和治愈率无统计学意义。结论伏立康唑治疗侵袭性真菌感染,是安全有效的;首选伏立康唑口服剂型治疗侵袭性真菌感染有望成为治疗效果好、成本低的推荐方法。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of voriconazole and ways to reduce health care costs in treating the invasive fugal infection.Methods Retrospective analysis of 43 cases of blood diseases combined invasive fungal infections,according to the different anti-fungal treatment program was divided into two groups.The group one was given intravenous voriconazole treatment,the first day loading dose(0.4g once per 12 hour),and then a maintenance dose(0.2g once per 12 hour);After the body temperature become normal and last one or two weeks,the oral voriconazole tablets was given at 0.2g once per 12 hour for maintenance therapy.The group two was given oral voriconazole tablets,the first day loading dose(0.4g once per 12 hour),and then a maintenance dose(0.2g once per 12 hour).Results There were four patients getting a transient elevated transaminases,two patients getting visual disturbances and two patients getting skin rashes.There were not occurrence of arrhythmia,kidney damage,edema and other adverse reactions.The efficiency of anti-fungal in group one was 79.2%,and 63.2% in group two;the cure rate of anti-fungal in group one was 54.2%,and 42.1% in group two,there was not a significant difference between the two groups(P>0.20).Conclusion Voriconazole to treat invasive fungal infections was safe and effective.First select oral formulation of voriconazole to treat invasive fungal infections was expected to become effective,low cost and the recommended method.更多还原