【摘要】 【目的】评价南蛇藤煎剂的安全性及不良反应。【方法】回顾分析90例服用南蛇藤煎剂的风湿病患者,检测服药前后的肝肾功能和血液分析。【结果】90例患者中,停药者15例,其中7例因无效停药,8例因不良反应停药(4例因服药后胃脘不适停药;3例因骨髓抑制停药;1例因月经量减少停药)。90例患者服药前后血细胞、肝肾功能比较,差异均无统计学意义(P>0.05)。【结论】南蛇藤煎剂不良反应包括性腺抑制、骨髓抑制及胃脘不适,对肝肾损害相对小,但由于患者个体差异,在用药期间特别是前3个月仍需密切监测其血液分析和肝肾功能。更多还原

【Abstract】 Objective To investigate the safety and adverse effect of Radix Celastri Orbiculati Decoction.Methods A retrospective analysis was carried out in 90 rheumatism patients who had taken Radix Celastri Orbiculati Decoction orally.The data of their hepatic and renal function as well as blood analysis were investigated.Results In 90 patients,15 gave up medication,7 for the treatment being ineffective and 8 for the adverse effect.The adverse effect was epigastric discomfort(involving 4 cases),bone marrow depression(involving 3 cases),and reduced menstrual blood volume(involving one case).The differences of blood cells,and hepatic and renal function were insignificant before and after treatment(P>0.05).Conclusion The adverse effect of Radix Celastri Orbiculati Decoction covers sexual gland depression,bone marrow depression and epigastric discomfort,and has mild damage to hepatic and renal function.For the individual difference,it will still be necessary to monitor the data of blood analysis and hepatic-renal function during the first 3 months of medication.更多还原