【摘要】 目的检测复发性外阴阴道念珠菌病患者念珠菌菌种分布及耐药状况,为临床治疗方案制订提供依据。方法120例患者依据病史分为复发性外阴阴道念珠菌病患者(RVVC)60例(病例组),偶发外阴阴道念珠菌病者(VVC)60例(对照组)。病例组及对照组分别进行真菌培养、菌种鉴定及药物敏感试验。结果在120株念珠茵中白念珠茵占80.83%,非白念珠茵占19.17%。RVVC组中白念珠茵占73.33%;VVC组中为白念珠茵占88.33%,RVVC组白念珠菌所占比例明显低于VVC组,差异有统计学意义(P<0,05)。60株RVVC念珠菌对两性霉素B、氟康唑和伊曲康唑的敏感率分别为100.00%、93.33%、95.00%。结论白念珠茵仍是VVC、RVVC的主要致病菌,RVVC分离菌株对咪唑类抗真菌药物仍有较高的敏感率。更多还原

【Abstract】 Objective To investigate the species of the clinical fungal isolates and the susceptibility to antifungal agents in recurrent vulvovaginal candidiasis patients.Methods 120 patients were divided into 2 groups:experiment group(60 patients with recurrent vulvovaginal candidiasis patients,RVVC group),and control group(60 incidental vulvovaginal candidiasis patients,VVC group).Strain culture,stain identification and susceptibility test were conducted in both groups.Results The most common specie was Candida albicans(80.83%).There were 7 non-Candidida albieans strains among 60 strains in VVC group(11.67%)and 16 non-Candidida albieans strains among 60 strains in RVVC group(26.67%).The ratio of non-Candidida albieans strains in RVVC group was significantly higher than that of VVC group(P<0.05).Drug susceptibility rates of the strains to amphotericin B,fluconazole,itraconazole were 100%,93.33%,95.00% respectively.Conclusion Candida albicans was the most common specie in VVC and RVVC.The clinical isolates from the RVVC cases are still highly sensitive to imidazoles.更多还原