【摘要】 目的探讨类风湿因子对免疫比浊法测定肌钙蛋白Ⅰ产生的干扰性假阳性及对策。方法选取类风湿因子在0～55IU/ml、56-109IU/ml、110IU/ml以上的患者标本各20例,且都无慢性支气管炎、肺心病、冠心病等器质性疾病,CK、CK-MB、AST、肌红蛋白(MYO)均正常、无黄胆及高脂血症的患者标本,用免疫比浊法测定肌钙蛋白I和电化学发光法测定肌钙蛋白T,分析类风湿因子对测定的干扰作用。结果类风湿因子在0～55IU/ml时对肌钙蛋白Ⅰ未造成干扰,在56～109IU/ml时可造成轻度干扰,在超过110IU/ml时可造成明显干扰。结论明显增高的类风湿因子会引起免疫比浊法测定肌钙蛋白Ⅰ出现假阳性,通过联合和连续监测CK、CK-MB、AST、肌红蛋白(MYO)以及分析临床资料,可以识别这种假阳性,以避免对临床诊治造成干扰。更多还原

【Abstract】 Objective To investigate the rheumatoid factor immune turbidimetric method,to determine troponin Ⅰ produced false-positive interference and countermeasures.Methods Selected rheumatoid factors in 0-55IU/mL,56-109IU/mL,110IU/mL with more than 20 cases specimens of patients,and no chronic bronchitis,Cor pulmonale,coronary artery heart disease and other organic diseases.CK,CK-MB,AST,myoglobin(MYO) were normal,no jaundice and Hyperlipidemia in patients with specimens with immunoturbidimetric determination of troponin Ⅰ and electro chemiluminescence determination of troponin T,analysis of rheumatoid factor on the determination of the interference effect.Results When the results of rheumatoid factor in the 0-55 IU/mL for Troponin I,no interference,in 56-109IU/mL caused mild interference,more than 110IU/mL caused significant interference.Conclusions Significantly higher rheumatoid factor causes the immune turbidimetric method false positive troponin I,and continuous monitoring by the Joint CK,CK-MB,AST,myoglobin(MYO),and analysis of clinical data can identify the false positive,clinical diagnosis and treatment in order to avoid causing interference.更多还原