【摘要】 目的探讨妊娠晚期应用拉米夫定对乙型肝炎病毒(HBV)DNA载量孕妇HBV垂直传播的阻断作用。方法将60例孕妇随机分为两组。对照组用乙型肝炎免疫球蛋白(HBIG)治疗,观察组给予拉米夫定治疗。分别检测孕妇和新生儿的各项指标。结果观察组孕妇分娩前HBV-DNA显著降低(P<0.05),新生儿出生24h内HBsAg和HBV-DNA阳性率显著低于对照组(P<0.05);观察组新生儿出生后6个月和1岁时HBsAb阳性率显著高于对照组(P<0.05)。结论于妊娠晚期应用拉米夫定可显著降低孕妇HBV-DNA载量,阻断HBV的母婴传播,安全有效。更多还原

【Abstract】 Objective To evaluate the blocking effect of lamivudine on HBV propagating in pregnant women.Methods 60 cases of gravidas were divided into two groups.Gravidas in control group were treated by HBIG and observation group by lamivudine.The index for gravidas and neonatus were evaluated.Results HBV-DNA value in observation group at ante partum was lower than control group(P<0.05).The positive rates of HBsAg and HBV-DNA for within 24h postpartum were lower than control group(P<0.05).The positive rates of HBsAb for neonatus in observation group 6 months and 1 year postpartum were higher than control group(P<0.05).Conclusions Treating the gravidas by lamivudine at late trimester of pregnancy can reduce the capacity of HBV-DNA and block the propagating.It is safe and effective.更多还原