【摘要】 目的:通过对鼻咽癌首次住院接受治疗患者的患病情况调查,了解鼻咽癌在珠海地区的临床患病特点,并与既往资料比较,为早期诊断提供依据。方法:回顾性调查分析2003-03-2011-03中山大学附属第五医院首次住院的626例鼻咽癌患者的病例资料。按预先设计的调查表,收集患者的首发症状、淋巴结肿大转移及颅神经侵犯等情况,并进行统计分析。结果:患者首发症状主要为颈部包块、涕血、耳鸣等症状,其中颈部包块为最典型的首发症状,占27.8%,涕血占23.0%,耳鸣占17.7%。颈部淋巴结转移423例(67.6%);在淋巴结转移的患者中,单侧转移314例(74.2%),双侧转移109例(25.8%),颈淋巴结以Ⅱ区转移最多见(90.0%),跳跃性转移率为4.7%。发生颅神经侵犯共103例(16.4%),以第Ⅴ、Ⅵ和Ⅻ对颅神经受累率较高,分别占5.4%、5.1%和3.7%。结论:颈部包块是鼻咽癌的典型首发症状,临床确诊时多在Ⅲ期;在珠海对当地基本人群进行健康宣教及体检普查,对于早期发现鼻咽癌有着十分重要的意义。更多还原

【Abstract】 OBJECTIVE:According to clinical data of patients with nasopharyngeal carcinoma,to analyse clinical features of Zhuhai City,and compared with previous data to provide a preference for prevention and treatment of nasopharyngeal carcinoma.METHODS:Clinical data of 626 patients who were diagnosed as nasopharyngeal carcinoma in fifth affiliated hospital of Sun Yat-sen university from March 2003 to March 2011 was collected and symptoms,node distribution and cranial never paralysis were analyzed in this study according to designed table.RESULTS: The most common initial symptom was neck mass with an incidence of 27.8%,followed by nasal bleeding(23.0%) and otological symptoms(17.7%).Of 626 patients 423(67.6%) had cervical lymphadenopathy at presentation.Of the 423 neck positive cases,the node involvement was unilateral in 74.2% patients and bilateral in 25.8%.The level Ⅱ was the most frequently involved area(90.0%),with the incidence of skip metastases was 4.7%.The cranial never involvement was 16.4% and the involvement for cranial neverⅤ,Ⅵ and Ⅻ was 5.4%,5.1% and 3.7% respectively.CONCLUSIONS:Nasal symptoms is the most common initial manifestation,and clinical diognosis is most in stage Ⅲ.It is significant for early diagnosis to carry out medical examination for healthy population in Zhuhai.更多还原