【摘要】 目的:探讨18F-氟化脱氧葡萄糖(18 F-FDG)与11 C-胆碱PET-CT联合应用在肺部占位性病变鉴别诊断中的价值。方法:选取196例肺部占位性病变患者,注射造影剂18F-FDG和11 C-胆碱后行PET-CT检查和诊断,观察2种造影剂PET-CT检查方法的标准摄取值(SUV)以及单独和联合应用的诊断灵敏度、特异性和准确率。结果:良性和恶性患者的18F-FDG(2.20±1.23 vs 5.29±2.75)及11 C-胆碱(0.81±0.79 vs 3.28±1.76)的SUVmax差异有统计学意义,P<0.01;18F-FDG和11 C-胆碱在良性及恶性患者中差异有统计学意义,P<0.01。18 F-FDG和11 C-胆碱PET-CT各自的灵敏度(58.16%vs 58.67%)、特异性(78.05%vs 84.00%)和准确率(80.61%vs 85.20%)差异无统计学意义,P>0.05。联合诊断的灵敏度、特异性和准确率分别为53.57%(105/196)、90.11%(82/91)和94.39%(185/196),与单独应用比较,灵敏度差异无统计学意义(P>0.05),特异性和准确率均提高,P<0.01。结论:将18 F-FDG和11 C-胆碱PET-CT检查联合运用于同一患者进行综合诊断能明显提高肺部占位病变的诊断水平。更多还原

【Abstract】 OBJECTIVE: To explore the diagnosis value of the combination of 18F-fluorinated deoxyglucose(18F-FDG) and 11C-choline PET-CT imaging in pulmonary occupying lesions.METHODS: Consecutive 196 patients with pulmonary occupying lesions from February 2009 to April 2011 in our hospital were performed 18F-FDG and 11C-choline PET-CT imaging,and the standardized uptake value(standard uptake value,SUV) of each tracer was measured for each lesion.The diagnostic sensitivity,specificity,and accuracy were compared for each single and the combination technique,respectively.RESULTS: There were statistically significant differences in 18F-FDG SUVmax(2.20±1.23 vs 5.29±2.75,P<0.01) and 11C-choline SUVmax(0.81±0.79 vs 3.28±1.76,P<0.01) between benign and malignant pulmonary lesions.The uptake of 18F-FDG in benign and malignant pulmonary lesion was also significantly different from the uptake of 11C-choline(P<0.01).There were no statistically significant difference among the sensitivity(58.16% vs 58.67%),specificity(78.05% vs 84.00%) and accuracy(80.61% vs 85.20%) between 18F-FDG and 11C-choline PET-CT imaging(P>0.05).Combining 18F-FDG and 11C-choline PET-CT imaging significantly increased the diagnostic specificity(90.11%,82/91) and accuracy(94.39%,185/196) than 18F-FDG or 11C-choline PET-CT imaging alone(P<0.01),although no enhancement in sensitivity(53.57%,105/196).CONCLUSION: Combining 18F-FDG and 11C-choline PET-CT imaging will significantly improve the diagnostic value in pulmonary occupying disease.更多还原