【摘要】 目的:初步探讨芦荟凝胶促进大鼠多柔比星外渗性损伤创面的愈合及其机制。方法:将45只多柔比星外渗性损伤模型大鼠随机分为生理盐水组(1mL/kg)、硫酸镁组(1mL/kg)和芦荟凝胶组(2.5g/kg),比较各组大鼠损伤程度及愈合率,ELISA方法检测各组大鼠在处理后1、4、7、11和18d损伤创面中TNF-α、IL-1β和IL-8的含量。结果:处理后18d3组愈合率分别为(38.20±7.10)%、(63.76±17.24)%和(65.84±16.21)%,芦荟凝胶能有效减轻外渗性创面损伤程度,P<0.05。ELISA方法显示,处理后18d两组TNF-α、IL-1β及IL-8含量分别为(14.55±3.13)、(19.63±4.56)ng/L,(9.86±2.78)、(13.81±2.57)ng/L,(5.56±1.46)、(9.01±4.05)ng/L,芦荟凝胶组与生理盐水组比较,TNF-α、IL-1β及IL-8含量明显降低,P<0.05。结论:芦荟凝胶能够显著减轻大鼠多柔比星外渗性损伤创面的损伤程度,促进愈合,其作用机制可能与其降低TNF-α、IL-1β及IL-8的含量有关。更多还原

【Abstract】 OBJECTIVE:To explore the possible mechanism of aloe gel on promote healing of injury in doxorubicin induced extravasation injury tissue in rats.METHODS:Forty five SD rats with extravasation injury model were randomly divided into NS group,magnesium sulfate group and aloe gel group.The healing rate and the degree of extravasation injury were compared,and after 1,4,7,11 and 18 days with different controls,the contents of TNF-α,IL-1β and IL-8 in the wound tissues were measured by ELISA.RESULTS:Aloe gel group can reduce the degree of injury,The wound healing rate of aloe gel group was signficantly higer than NS group(P<0.05).Eighty days after treatment inthree groups of healing rates were(38.20±7.10)%,(63.76±17.24)%,(65.84±16.21)%.The contents of TNF-α,IL-1β and IL-8 of aloe gel group was obviously lower than those in NS group(P<0.05).The differencere were significant compared NS group.Eighty days after treament in two groups of TNF-α,IL-1β and IL-8 contents were(14.55±3.13),(19.63±4.56),(9.86±2.78),(13.81±2.57),(5.56±1.46),(9.01±4.05) ng/L.CONCLUSIONS:Aloe gel can significantly reduce the extravasation injury and promote healing.The mechanism of the findings is associated with inhibit contents of TNF-α,IL-1β and IL-8 in extravasation injury tissue.更多还原