【摘要】 目的探讨人巨细胞病毒(HCMV)激活感染与肿瘤坏死因子α(TNF-α)水平和颈动脉粥样硬化斑块性质的关系。方法采用免疫荧光法检测外周血白细胞HCMV-PP65抗原,以其作为HCMV激活感染的指标,对212例颈动脉粥样硬化患者分别进行HCMV-PP65抗原、TNF-α水平检测和颈动脉超声检查。结果 HCMV-PP65抗原阳性组TNF-α含量为(3.04±0.37)μg/L与HCMV-PP65抗原阴性组(1.37±0.17)μg/L比较,差异有统计学意义(P<0.01);HCMV-PP65抗原阳性组存在不稳定性斑块的患者44例(69.84%),HCMV-PP65抗原阴性组存在不稳定性斑块的患者72例(48.32%),两组比较差异有统计学意义(χ2=8.82,P<0.01)。结论 HCMV激活感染可引起TNF-α水平增高,可能与颈动脉粥样硬化斑块不稳定性有关。更多还原

【Abstract】 Objective To study the correlation of human cytomegalovirus(HCMV) active infection with TNF-α and character of carotid atherosclerotic plaque.Methods HCMV-PP65 antigen in peripheral blood leukocytes was detected by immunofluorescence and was used as an indicator of active HCMV infection.HCMV-PP65 antigen,TNF-α and carotid ultrasonography were detected in 212 patients with carotid atherosclerosis.Results The levels of TNF-α in HCMV-PP65 antigen positive group and HCMV-PP65 antigen negative group were(3.04±0.37)μg/L and(1.37±0.17)μg/L respectively,and the difference between the two groups was statistically significant(P<0.01).44 cases(69.84%) in HCMV-PP65 antigen positive group had unstable plague,while 72 cases(48.32%) in HCMV-PP65 antigen negative group had unstable plague,and the difference was statistically significant(χ2=8.82,P<0.01).Conclusion Active infection of HCMV can induce TNF-α level to increase and it may be associated with the instability of carotid atherosclerosis plaque.更多还原