【摘要】 目的通过流行病学调查,了解新疆哈萨克族代谢综合征(MS)的患病情况,比较美国国家胆固醇教育计划成年人治疗方案第三次报告(ATPⅢ)、国际糖尿病联盟(IDF)和中华医学会糖尿病学分会(CDS)建议的MS诊断标准在哈萨克族人群中应用的差异。方法对新疆地区2 219例哈萨克族居民进行横断面调查,根据3种诊断标准分别计算MS的患病率,分析不同诊断标准下MS异常组分及危险因素聚集的检出情况,比较3种诊断标准在哈萨克族人群中的一致性。结果 3种诊断标准的患病率(标准化患病率)分别为23.21%(21.29%)、23.88%(21.96%)和18.21%(16.65%)。3种标准对MS患者3个以上危险因素聚集的检出率分别为100.00%、96.23%和91.34%,其检出率比较差异有统计学意义(χ2=46.534,P=0.000)。3种诊断标准在哈萨克人群中应用的一致性两两比较,ATPⅢ标准与IDF标准的一致性较好(一致率为0.9878,Youden指数为0.9568,Kappa值为0.9662),CDS标准与另外两种标准(ATPⅢ和IDF)的一致性不高。结论 3种MS诊断标准在新疆哈萨克族人群中应用时,获得的患病率、危险因素聚集情况和一致性差异较大,IDF标准检出率最高,ATPⅢ标准对危险因素聚集检出率最高,且两者一致性较好,优于CDS标准。更多还原

【Abstract】 Objective To understand the prevalence of metabolic syndrome(MS) among Xinjiang Kazak population through epidemiological investigation and to compare the difference of MS diagnostic criteria recommended by National Cholesterol Education Program(ATPⅢ),International Diabetes Federation(IDF) and Chinese Medical Association Diabetes Branch(CDS) in Kazak population.Methods A cross-sectional study was conducted on 2 219 Xinjiang Kazak people.The prevalence of MS was calculated and the MS abnormal components and detection of risk factors cluster under different criteria were analyzed.The diagnosis consistency of the three criteria in Kazak population was compared.Results The prevalence(standardized prevalence) according to three criteria was 23.21%(21.29%),23.88%(21.96%) and 18.21%(16.65%) respectively.The detection rate of risk factors cluster having more than three risk factors in MS patients was 100.00%,96.23% and 91.34% respectively according to the three criteria,and the difference was statistically significant(χ2=46.534,P=0.000).When the three criteria were compared pairwise,the ATPⅢ and IDF had good diagnosis consistency(agreement rate was 0.9878,Youden index was 0.9568 and Kappa index was 0.9662).The CDS had low consistency with the other two criteria(ATPⅢ and IDF).Conclusion The prevalence,risk factors cluster and consistency all show significant difference in Xinjiang Kazak population under the three MS diagnostic criteria.IDF has the highest detection rate and ATPⅢ has the highest detection rate of risk factors cluster,and the two criteria have good diagnosis consistency,making them superior to CDS.更多还原