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那他霉素微胶囊的制备及性能测试

Preparation of Natamycin Microcapsule and Its Properties

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【作者】 郑雅婧卢向阳巨修练卢彩鸽刘伟成高攀

【Author】 ZHENG Ya-jing1,LU Xiang-yang2,JU Xiu-lian1,LU Cai-ge2,LIU Wei-cheng2,GAO Pan3(1.School of Chemical Engineering & Pharmacy,Wuhan Institute of Technology,Wuhan 430074,China; 2.Institute of Plant & Enviromental Protection,Beijing Academy of Agricultural and Forestry Science,Beijing 100097,China;3.Agriculture College,Yangtze University,Jingzhou 434023,Hubei,China)

【机构】 武汉工程大学化工与制药学院北京市农林科学院植物保护环境保护研究所长江大学农学院

【摘要】 [目的]利用微胶囊技术提高那他霉素(NA)的抗光解性能。[方法]复凝聚法,以明胶和阿拉伯胶作壁材,以正交试验优化工艺,测试微胶囊释放和抗光解。[结果]优化工艺为壁材质量浓度20 g/L、芯壁比1.5∶1、反应pH值4.5、反应时间90 m i n;以水和30%甲醇溶液为释放介质,微胶囊具良好的通透性和缓释性;在紫外光下,NA微胶囊相对活性下降50%的时间为79 min,较NA浓缩液和NA悬乳剂(含UV-531)分别提高3.0倍和1.1倍。[结论]NA微胶囊可显著提高NA的抗光解性能,作为农用杀菌剂具较大潜力。

【Abstract】 [Aims] Microcapsulation was utilized to increase natamycin(NA) photostability.[Methods] With gelatin and gum arabic as wall materials,NA microcapsule was prepared by complex coacervation and the process was optimized with orthogonal test.And also its release and anti-photolysis were determined.[Results] Optimal process was as follows: 20 g/L concentration of wall material,core/wall 1.5∶1(w/w),reaction pH 4.5 and reaction time 90 min.Good permeability and control release of the microcapsule were got in water and 30% methanol solution.It took 79 min for the relative activity of the microcapsule to decrease by 50% under UV,which increased by 3.0 and 1.1 times compared with NA concentrate and susupended emulsion with UV-531,respectively.[Conclusions] The microcapsule could significantly improve NA photostability and showed a good prospect as agricultural fungicide.

【基金】 北京市科技计划(Z101105052010002);北京市农林科学院项目(2010A006);北京市农林科学院植环所创新基金项目(CXJJ2010A02)
  • 【分类号】TQ450.6
  • 【被引频次】20
  • 【下载频次】176
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