【摘要】 游离RNA(cell-free RNA,cfRNA),即存在于细胞外的转录产物,包括mRNA和microRNA,在人的多种体液中被广泛研究并成为疾病无创性诊断和研究的新分子标志物。近年来发现精浆游离RNA,即cfsRNA(cell-freeseminal RNA),具有诸多优势,具备作为无创性分子标志物的基本条件,并可能为男性生殖系统遗传学改变提供可靠信息,在男性生殖系统疾病诊断和研究方面展示出良好的应用前景。本文结合其一般特征、作为新分子标记物及在男性生殖系统疾病诊断和研究方面的现状和展望作一综述。更多还原

【Abstract】 Cell-free RNAs(cfRNAs),including mRNA and microRNA,are transcripts existing outside cells.These extracellular RNAs have been detected in many kinds of human body fluids and reported as promising noninvasive biomarkers for disease diagnosis and research.Recent studies discovered the presence of cfRNAs in human seminal plasma and revealed its general characteristics.Cell-free seminal RNA has been proposed as a novel noninvasive biomarker for male infertility and forensic identification.This review focuses on the general characteristics,current application,and perspective of cfRNAs.更多还原