【摘要】 目的:提高超声引导下甲状腺细针穿刺(US-FNAB)对于甲状腺疾病的诊断水平。方法:回顾性分析南京医科大学第一附属医院内分泌科2011年5月～2012年1月1 016份US-FNAB细胞病理报告,同时对比分析其中44例接受外科手术患者的组织病理报告。结果:1 016例报告中怀疑或确定为恶性肿瘤72例(7.09%),132例诊断为甲状腺囊性变,占12.99%。明确诊断慢性淋巴细胞性甲状腺炎165例(16.24%)、亚急性甲状腺炎56例(5.51%)。对44例接受手术患者的资料进一步分析得出,US-FNAB对于恶性或怀疑为恶性疾病诊断的敏感性为65.22%,特异性为76.19%,阳性预测值为75.00%,阴性预测值为66.67%,假阳性率为25.00%,假阴性率为33.33%。总体阳性细胞率85.24%。结论:US-FNAB对于甲状腺良恶性结节的鉴别,对于甲状腺囊性变、慢性淋巴细胞性甲状腺炎、亚急性甲状腺炎的细胞病理诊断有非常重要的价值。更多还原

【Abstract】 Objective:To improve the capability of ultrasound-guided fine-needle aspiration biopsy(US-FNAB) in diagnosing thyroid diseases.Methods:Total 1 016 US-FNAB cytopathological cases were analyzed retrospectively from May 2011 to Jan 2012 in Department of Endocrinology,the First Affiliated Hospital of NJMU.Meantime,44 histological pathological reports from these patients were analyzed.Results:Among 1 016 US-FNAB cytopathological reports,72 cases(7.09%) were labelled as malignant or suspicious for malignancy while confirmative cytopathological diagnosis for capsula glandulae thyroideae,chronic lymphocytic thyroiditis(CLT) and subacute thyroiditis were seen in 132(12.99%),165(16.24%),and 56(5.51%) cases.By combining cytological result of USFNAB and histological pathological results of sugery,the sensitivity,specificity,positive predictive value,negative predictive value,false positive rate and false negative rate were calculated as following 65.22%,76.19%,75.00%,66.67%,25.00% and 33.33%.Total positive cell rate was 85.24%.Conclusion:US-FNAB showed great importance in differentiation between benign and malignant thyroid lesions and in diagnosing capsula glandulae thyroideae,chronic lymphocytic thyroiditis and subacute thyroiditis.更多还原