【摘要】 目的探讨血清脂联素(APN)、尿酸水平与冠心病及其病变严重程度的关系。方法选取112例行冠状动脉造影的患者,分为3组,急性冠状动脉综合征(ACS)患者58例,稳定型心绞痛患者25例,非冠心病患者29例,进行血清APN、尿酸测定。冠状动脉病变程度用冠状动脉病变支数及Gensini积分表示,按病变范围分为对照组(29例)、单支病变组(24例)、双支病变组(26例)、三支病变组(33例);按Gensini积分分为0～1分组(29例)、2～20分组(28例)、21～40分组(30例)、>40分组(25例)。结果 ACS组APN水平显著低于对照组和稳定型心绞痛组(均<0.05);血尿酸水平显著高于对照组和稳定型心绞痛组(均<0.05)。对照组APN水平显著高于单支、双支和三支病变组(均<0.05);而对照组血尿酸水平显著低于单支、双支和三支病变组(均<0.05)。0～1分组和2～20分组APN水平分别显著高于21～40分组和>40分组(均<0.05)。APN水平与Gensini积分的对数呈负相关(=-0.584,<0.05);0～1分组和2～20分组血尿酸水平分别显著低于21～40分组和>40分组(均<0.05)。血尿酸水平与Gensini积分的对数呈正相关(r=0.348,<0.05)。结论 APN、尿酸水平与冠状动脉稳定性、狭窄程度以及范围显著相关,有助于临床评价冠心病病变程度及其进展。更多还原

【Abstract】 Objective To investigate the correlation between serum adiponectin and uric acid level and severity of coronary artery disease.Methods The serum concentrations of adiponectin and uric acid in 112 patients who had received CAG were divided into three groups: 58 cases with acute coronary artery syndrome(s ACS,ACS group),25 cases with stable angina pectori(s stable angina pectoris group)and 29 cases with non-coronary disease(control group).Adiponectin and uric acid were measured.The severity of coronary artery lesion was evaluated by the number of stenosis vessel and Gensini score.According to the lesion scope,there were four groups: control group(=29),single vessel lesion group(=24),double-vessel lesion group(=26)and triple vessel lesion group(=33);according to Gensin scores,there were also four groups: score 0 ～ 1 group(=29),score 2 ～ 20 group(=28),score 21 ～ 40 group(=30),score > 40 group(=25).Results Patients with acute coronary syndrome had lower adiponectin levels than those without coronary heart disease and those with stable angina pectori(s < 0.05).Patients with acute coronary syndrome had higher uric acid levels than those without coronary heart disease and those with stable angina pectori(s < 0.05).The serum concentrations of adiponectin in the control group were significantly higher than those in the single vessel lesion group,double-vessel lesion group and triple vessel lesion group(< 0.05).The serum concentrations of uric acid in the control group were significantly lower than those in the single vessel lesion group,double-vessel lesion group and triple vessel lesion group(< 0.05).TheserumconcentrationsofadiponectininGensiniscore0 ～ 1groupandscore2 ～ 20groupwererespectively higher than those in score 21 ～ 40 group and score > 40 group(< 0.05).Serum adiponectin concentration were negatively correlated with the log of Gensini score(=-0.584,< 0.05).The serum concentrations of uric acid in Gensini score 0 ～ 1 group and score 2 ～ 20 group were respectively lower than those in score 21 ～ 40 group and score > 40 group(< 0.05).Serum uric acid concentration were positively correlated with the log of Gensini score(= 0.348,< 0.05)Conclusions The decrease in serum adiponectin and the increase in serum uric acid might reflect increase in severity of coronary artery stenosis.更多还原