【摘要】 目的:考察苗医验方"四大血"抗炎作用及其急性毒性。方法:用"四大血"不同浓度水提物及醇提物对小鼠进行耳肿胀、足肿胀、棉球肉芽肿胀以及腹腔通透性试验,用"四大血"水提醇沉液对小鼠进行急性毒性试验。结果:与阴性组比较,"四大血"的水高组、水中组、醇高组耳肿胀度显著降低,差异有统计学意义(P<0.05或P<0.01);"四大血"水高组、醇高组、醇中组足趾肿胀度显著降低,差异有统计学意义(P<0.05或P<0.01);棉球肉芽肿胀试验中,各组肉芽重量均显著降低,差异有统计学意义(P<0.05或P<0.01);腹腔通透性试验,除"四大血"的水低组、醇低组外,其余各组通透性均显著降低,差异有统计学意义(P<0.05或P<0.01);"四大血"口服LD50为404.18g/kg。结论:"四大血"有明显的抗炎作用,使用安全。更多还原

【Abstract】 Objective: Examine the anti-inflammatory effects of the Hmong prescription called "sidaxue" and the Acute toxicity test.Methods:Complete ear swelling,foot swelling,swelling of granuloma and peritoneal permeability test on mice in different concentrations of water extraction liquid,the alcohol extract of "sidaxue"and the acute toxicity test in water extraction and alcohol precipitation solution.Result: High-water group,the water group and the high alcohol group ear swelling significantly reduced compare with the blank group,the difference has statistically significant(P<0.05 或P<0.01).High-water group,alcohol group,alcohol group paw edema was significantly lower,,the difference has statistically significant(P<0.05 或P<0.01).Each group of granulation weight were significantly lower in granuloma expansion test,the difference has statistically significant(P<0.05 或P< 0.01).Except the low-water group and the low-alcohol group,the rest of the group permeability were significantly lower in abdominal permeability test,the difference has statistically significant(P<0.05 或P<0.01).The LD50 of "sidaxue" is 404.18g/kg.Conclusion: "Sidaxue" has a obvious anti-inflammatory effects and it’s safe to use.更多还原