【摘要】 目的探讨甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)定量检测在甲状腺肿大患者病因诊断上的应用。方法对291例甲状腺肿大患者血清和86例正常人血清用直接化学发光定量检测TGAb和TPOAb,并对甲状腺肿大患者检测甲功5项。结果甲状腺肿大患者TGAb和TPOAb浓度分别为(254±417)U/ml和(1001±1108)U/ml,有124例确诊为自身免疫性甲状腺炎(AITT),90例诊断为单纯性甲状腺肿大;AITT患者TGAb和TPOAb浓度和抗体检出率明显高于非AITT患者,P<0.01。结论定量检测血清TGAb和TPOAb对甲状腺肿大患者在病因诊断上有重要意义。更多还原

【Abstract】 This study aims to explore the application of quantitative detection of thyroglobulin antibody(TGAb) and thyroid peroxidase antibody(TPOAb) in etiological diagnosis of patients with goiter.The serum samples from 291 goiter patients and 86 normal individuals were tested by direct chemiluminescent for TGAb and TPOAb quantitative detection,and thyroid enlargement patients were further checked for 5 items of thyroid functions.We found that the TGAb and TPOAb levels of goiter patients are(254±417) U/ml and(1001±1108) U/ml respectively.Total of 124 cases were diagnosed with autoimmune thyroiditis(AITT),and 90 cases were diagnosed of pure thyromegaly.And in AITT patients,the TGAb and TPOAb concentrations as well as the antibody detection rate were significantly higher than those of non-AITT patients(P < 0.01).As we come to the conclusion,the quantitative analysis of serum TGAb and TPOAb shows significant application value in the etiological diagnosis for patients with goiter.更多还原