【摘要】 目的:探索Tenas ci n C在瘢痕疙瘩组织的表达及其意义。方法:使用免疫组化方法对15例瘢痕疙瘩组织和正常皮肤组织成纤维细胞表达的Tenasci n C表达进行检查。结果:与正常皮肤成纤维细胞相比,瘢痕疙瘩成纤维细胞高表达Tenasci n C,具有显著差异,P<0.01。结论:瘢痕疙瘩成纤维细胞自分泌产生Tenasci n C,在瘢痕疙瘩组织高表达,是瘢痕疙瘩组织的特异性标志物。更多还原

【Abstract】 Objective To explore the expression of Tenascin C in keloid and its significance.Methods Immunohistochemical technique method was used to dected the level of Tenascin C in 15 cases keloidal and normal fibroblasts in vitro.Results tenascin C expression was increased significantly in keloidal fibroblasts(P<0.01).Conclusion Therefore,tenascin C is a marker associated with keloids and we suggest that keloidal fibroblasts,once stimulated,continue to produce tenascin C independently from circulating factors.更多还原