【摘要】 目的:探讨冠心病患者外周血中性粒细胞(PMN)活化与冠状动脉狭窄程度及肌钙蛋白T(CTnT)的关系;方法:82例冠心病患者,包括38例急性心肌梗死(AMI)、23例不稳定型心绞痛(UA)、21例稳定型心绞痛(SA)患者、30例正常对照,采用流氏细胞技术检测中性粒细胞粘附分子CD11b/CD18和CD62L,同时作冠状动脉造影定量分析冠状动脉病变积分(CAS),以评价冠状动脉狭窄程度,并测量心肌肌钙蛋白T。结果:冠心病患者存在CD62L表达的下调和CD11b/CD18表达的上调,AMI患者比UA患者明显,UA患者比SA患者明显,而SA患者仅在CD11b/CD18表达上高于正常组;CTnT阳性与阴性患者相比,其CD62L表达下降而CD11b/CD18表达增高;CAS在SA、UA与AMI患者间,CTnT阳性组与阴性组间均无明显差异;相关性分析显示:CTnT与CD62L成负相关、与CD11b/CD18成正相关,且相关性较好,CD62L与CD11b/CD18成负相关,而CAS与CD62L及CD11b/CD18的相关性无统计学意义。结论:在冠心病患者尤其是UA和AMI患者中,PMN是处于活化状态的,尤其是PMN表面细胞粘附分子CD62L和CD11b/CD18,在冠心病患者尤其是急性冠脉综合征的发生发展中起到了重要作用。更多还原

【Abstract】 Objective:To investigate the relation between polymorphonuclear neutrophil(PMN) activation and coronary artery score and troponin T(cTnT) of coronary artery disease(CAD).Methods:82 CAD patients including 23 unstable angina pectoris(UA),38 acute myocardial infarction(AMI) and 21 stable angia pectoris(SA).CD62L and CD11b/CD18 on polymorphonuclear neutrophils were analyzed by flow cytometry.The severity of coronary artery lesions was quantitative analysed by coronary arteriongraphy,coronary artery score(CAS) was calculated, and CTnT were detected.Results:Expression of CD62L was significantly lower and CD11b/CD18 higher in CAD patients,and they were more significant in AMI than in UA,and similar results were more often found in UA than in SA;and there was similar change between CTnT positive and CTnT negative;and no difference in CAS between UA and AMI,CTnT positive and cTnT negative.There was notably negative correlation between CTnT and CD62L,CTnT and CD62L,positive correlation between cTnT and CDllb/CD18;and no correlation between CAS and CD62L,CAS and CD11b/CD18.Conclusion:There exists PMN activation among CAD patients,and the detection of CD62L and CD11b/CD18 may play an important role in the development of CAD.更多还原