【摘要】 目的评价脑白质疏松症(LA)临床相关危险因素之间的相关性及预测病情的价值。方法回顾性调查行头颅MRI检查的住院患者218例,根据诊断分为非LA 56例和LA 162例,LA患者又根据Fazekas等级分类标准,分为轻度LA 52例,中度LA 53例及重度LA 57例。对相关危险因素(年龄、性别、既往疾病、血脂等)分别进行逐个单因素和多因素logistic回归分析。结果 TC、高LDL-C、高同型半胱氨酸与轻度LA发生有相关性(P<0.05,P<0.01)。年龄≥70岁、高血压3级、吸烟、高TC,高同型半胱氨酸与中度LA的发生有相关性(P<0.05,P<0.01)。年龄≥70岁、高血压3级、高LDL -C、高同型半胱氨酸、颈动脉内膜中层厚度增厚与重度LA的发生有相关性(P<0.05)。结论年龄≥70岁、高血压3级、高同型半胱氨酸、高TC、高LDL-C、吸烟及颈动脉内膜中层厚度增厚是LA的独立发病危险因素。中度LA和重度LA与年龄≥70岁、高血压3级及颈动脉内膜中层厚度增厚有明显相关性。更多还原

【Abstract】 Objective To assess the correlation between leukoaraiosis(LA)-related risk factors and its value in predicting the condition of LA.Methods Two hundred and eighteen patients admitted to our hospital for cranial MRI were divided into non-LA group(n = 56) and LA group(n= 162). Patients in LA group were further divided into mild LA group(n = 52),moderate LA group(n = 53),and severe LA group(n = 57) according to the Fazekas classification.Their relative risk factors, including age,gender,history of disease,and blood-lipid,were analyzed by single and multifactorial logistic regression analysis.Results The TC,LDL-C and high homocysteine were related with mild LA(P<0.05,P<0.01).Age≥70 years,hypertension grade 3,smoking,high cholesterol and high homocysteine were related with moderate LA(P<0.05,P<0.01).Age≥70 years,hypertension grade 3,LDL-C,high homocysteine and carotid intima-media thickness were related with severe LA(P<0.05,P<0.01).Conclusion Age≥70 years,hypertension grade 3, high homocysteine,TC,LDL-C and carotid intima-media thickness are the independent risk factors for LA.Moderate and severe LA are closely related with age≥70 years,hypertension grade 3 and carotid intima-media thickness.更多还原