【摘要】 目的了解胱抑素C水平与冠状动脉病变严重程度的关系。方法选择疑诊冠心病且行选择性冠状动脉造影的冠心病患者114例(冠心病组).根据临床病史和冠状动脉造影结果分为2组:急性冠状动脉综合征(acute coronarysyndromes,ACS)组73例,稳定性心绞痛(stable angina pectoris,SAP)组41例;另选择非冠心病(冠状动脉造影阴性)患者38例作为对照组。采用Gensini评分系统对冠状动脉病变程度进行评分。应用免疫比浊法测定血清胱抑素C水平。分析血清胱抑素C水平与冠状动脉病变严重程度及病变支数的相互关系。结果 ACS组和SAP组血清胱抑素C水平明显高于对照组[(2.2±3.5)mg/L vs(1.6±4.1)mg/L vs(0.7±2.9)mg/L,P<0.01].且ACS组血清胱抑素C水平明显高于SAP组(P<0.05)。Gcnsini积分≥30分患者血清胱抑素C水平明显高于Gensini积分<30分患者[(2.6±2.7)mg/L vs(1.8±5.2)mg/L,P<0.01]。3支病变患者血清胱抑紊C水平和Gensini积分较单支病变和双支病变患者明显增高[(2.8±1.8)mg/L vs(1.9±3.4)mg/L vs(2.1±4.1)mg/L;(49±16)分v5(17±9)分vs(28±1 8)分,P<0.05,P<0.01];双支病变患者Gensin积分较单支病变患者明显增高(P<0.01);而单支病变与双支病变患者血清胱抑素C水平差异无统计学意义(P>0.05)。血清胱抑素C水平与冠状动脉病变严重程度Gensini积分呈正相关(r=0.673,P<0.01)。结论胱抑素C水平与冠状动脉病变严重程度及病变支数显著相关,胱抑素C水平可以作为评价冠状动脉病变严重程度的一个指标。更多还原

【Abstract】 Objective To study the correlation between cystatin C level and severity of coronary heart disease(CHD).Methods One hudred and fourteen patients with CHD were divided into acute coronary syndrome(ACS) group(n= 73) and stable angina pectoris(SAP) group(n= 41). Thirty-eight non-CHD patients with negative coronary angiogragraphy(CAG) served as a control group.Severity of CHD was scored using the Gensini scoring system.Correlation of serum cystatin C level and severity of CHD with lesions of coronary arteries was analyzed.Results The serum cystatin C level was significantly higher in ACS group and SAP group than in control group (2.2±3.5 mg/L vs 1.6±4.1 mg/L vs 0.7±2.9 mg/L,P<0.01),in ACS group than in SAP group(P<0.05),in patients with their Gensini score≥30 than in those with their Gensini score<30(2.6±2.7 mg/L vs 1.8±5.2 mg/L,P<0.01),and in patients with triple vessel disease than in those with single vessel disease(P<0.01),but no significant difference was found between patients with triple vessel disease or single vessel disease(P>0.05).The cystatin C level was positively correlated the Gensini score of CHD severity(r= 0.673,P<0.01).Conclusion Cystatin C level is significantly correlated with the severity of CHD and the number of compromised coronary arteries,and can thus be used as a marker in assessing the severity of CHD.更多还原