【摘要】 目的:评价乌司他丁（UTI）治疗急性左心衰的临床疗效及安全性。方法:将120例急性左心衰的患者随机分为治疗组62例和对照组58例,治疗组在常规抗心衰治疗的基础上给予UTI 10万U溶入0.9%氯化钠（NS）注射液10 mL中缓慢静脉注射,Q8h,对照组在常规抗心衰治疗的基础上给予安慰剂0.9%NS 10 mL缓慢静脉注射,Q8h,观察3天后两组患者的心率（HR）、呼吸（R）、血压（BP）、动脉血氧饱和度（SaO₂）、心衰标志物N末端B型利钠肽原（NT-proBNT）改善情况及患者的平均住院时间和院内死亡率。结果:治疗组HR、R、B P、SaO₂、NT-proBNT改善情况及患者的平均住院时间和院内死亡率均优于对照组（P<0.05）。结论:UTI是辅助治疗急性左心衰安全有效的药物,建议临床推广应用。更多还原

【Abstract】 Objective:To evaluate the efficacy and safety of acute left heart failure(ALHF) treated by Ulinastatin(UTI).Methods;120 patients with ALLHF were randomly assigned into treatment group(n=62) and control group(n=58).The treatment group were slowly and intravenously injected(Q8h) with 10 mL 0.9%normal saline dissolving 100 000 units UTI on the base of regular anti-heart failure treatment.The control group were slowly and intravenously injected(Q8h) with 10 mL 0.9%normal saline.The heart rate(HR),respiration(R),blood pressure(BP),saturation oxygen of artery(SaO2),N-terminal B-type natriuretic peptide(NT-proBNT),the mean hospital stay and hospital mortality were observed after treatment three days.Results;The improvement of HR,R,BP, Sa02,NT-proBNT,the mean hospital stay and hospital mortality in the treatment group were all significantly better than those of control group(P<0.05).Conclusions;UTI is efficacy and safety to treat ALHF,which deserves to be popularized in clinic.更多还原