【摘要】 目的研究恶性肿瘤患者以及不同感染性疾病患者血清中sMICA分子的含量及临床意义。方法采用ELISA法检测1041例恶性肿瘤及感染性疾病患者和141例正常对照个体血清sMICA分子含量,分析其相关性及诊断价值。结果与正常对照组相比,肝癌患者的血清sMICA含量明显升高(P<0.05)。某些细菌(肠杆菌、结核杆菌、非发酵革兰阴性菌和革兰阳性球菌)、病毒(HBV和HCV)以及梅毒螺旋体感染患者的血清sMICA含量也明显高于正常对照组(P<0.05)。结论血清中sMICA分子含量对肝癌及部分感染性疾病具有一定的辅助诊断价值。肠杆菌、结核杆菌、非发酵革兰阴性菌、革兰阳性球菌、HBV、HCV及梅毒螺旋体感染可导致血清sMICA分子增高。更多还原

【Abstract】 Objective To identify the levels of serum soluble major histocompatibility complex class I chain-related gene A(sMICA) protein in patients with malignant tumor/infectious diseases and explore its clinical significance.Methods The serum sMICA levels were determined by enzyme-linked immunosorbent assay(ELISA),including patients(n=1041) suffering from several types of malignant tumors and infectious diseases and healthy controls(n=141).The correlation and diagnostic value were analyzed.Results Compared with the controls,serum sMICA elevation was significantly increased in patients of hepatic cancer(P<0.05).The sMICA levels of patients with bacterial(Enterobacteriaceae,Mycobacterium tuberculosis,non-fermenting Gram-negative bacteria and Gram-positive cocci),viral(hepatitis B and C) and the Microspironema pallidum infections were also significantly higher than that of the controls(P<0.05).Conclusion Serum sMICA levels may be informative for the diagnosis of hepatic cancer and some infectious diseases.Serum sMICA elevation may be caused by Enterobacteriaceae,Mycobacterium tuberculosis,non-fermenting Gram-negative bacteria,Gram-positive cocci,HBV,HCV and the Microspironema pallidum.更多还原