【摘要】 [目的]探讨职业二甲基乙酰胺(DMAC)接触与尿中甲基乙酰胺(NMAC)的相关性。[方法]对3家氨纶生产企业6个工种201名工人进行空气中DMAC暴露浓度监测及工作周末班末尿样采集,同时对20名纺丝工连续一周空气样品和班末尿样的采集;分别用气相色谱测定空气中DMAC和尿中NMAC含量。[结果]氨纶生产过程中组件清洗工、纺丝工接触DMAC水平最高(P<0.0033),中位数分别为32.10、22.02mg/m3,其尿中NMAC浓度较其他工种高(P<0.0033),中位数分别为30.09、22.72mg/gCr;工作周末班末尿NMAC含量与空气中DMAC浓度呈直线相关,直线方程为log(U-NMAC)=0.685+0.455×log(A-DMAC)(r=0.698,P=0.001);长期DMAC接触者,接触2d后尿中NMAC呈较高水平(P<0.0033);个体DMAC接触代谢转化为NMAC的相对内暴露指数(RIE)与DMAC接触浓度呈负相关(rs=-0.781,P=0.001)。[结论]工作周末班末尿NMAC含量与空气中DMAC浓度呈良好对数线性关系。更多还原

【Abstract】 [Objective] To examine the correlation between occupational N,N-dimethylacetamide(DMAC) exposures and urinary N-methylacetamide(NMAC).[Methods] A total of 201 workers of 6 work types exposed to DMAC in 3 spandex factories were recruited.Air samples were collected from each work type site,post-shift urine samples at the end of workweek were collected from all studied workers and also from 20 spinning workers at each end of workday for 5 consecutive days.NMAC in urine and DMAC in air were determined by gas chromatography.[Results] The time-weighted average(TWA) air levels of DMAC were highest in module washing and spinning sites(P < 0.003 3),medians being 32.10 and 22.02 mg/m3 respectively.The urinary NMAC concentrations in module washing workers and spinning workers were significantly higher than workers of other work types,medians being 30.09 and 22.72 mg/gCr respectively.A linear correlation was found between the TWA air levels of DMAC and the creatinine-adjusted NMAC levels in urine collected by the end of workweek(r=0.698,P = 0.001).The linear equation was log(U-NMAC)= 0.685+0.455×log(A-DMAC).After 2 consecutive days of exposure,the urinary NMAC was at a higher level in chronically exposed workers(P < 0.003 3).A negative linear correlation was found between the DMAC levels in air and the relative internal exposure(RIE)(rs=-0.781,P = 0.001).[Conclusion] Air DMAC contents are significantly correlated with urinary NMAC concentrations after logarithmic transformation.更多还原