【摘要】 目的探讨螺旋断层放疗技术治疗髓母细胞瘤的剂量学优势、不良反应及疗效。方法 2011年2月至2011年10月,4例髓母细胞瘤患者接受螺旋断层放射治疗。术后瘤床临床靶区(CTV1)剂量:50.4Gy/28f,每次1.8Gy,5次/周;全脑全脊髓临床靶区(CTV2)剂量:30.6Gy/17f,每次1.8Gy,5次/周。结果 4例患者接受照射的均匀性和适形性较好,重要器官的照射剂量低,治疗时间均小于15min。4例患者均获随访,中位随访9个月(4～15个月),至随访截止时间无1例复发。主要不良反应为骨髓抑制和恶心呕吐,4例患者均可耐受。结论螺旋断层放疗治疗髓母细胞瘤的疗效和剂量分布较好,为治疗髓母细胞瘤开辟了一个新的治疗平台。更多还原

【Abstract】 Objective To explore the efficacy,side effects and dosimetry advantage of tomotherapy on medulloblastoma.Methods Four patients with medulloblastoma were treated with tomotherapy from February 2011 to October 2011.CTV1 was the tumor bed after operation,and the prescription dose was 50.4Gy(for 28 times,1.8Gy for each time,5 times/week).CTV2was the whole brain and spinal cord,and the prescription dose was 30.6Gy(for 17 times,1.8Gy for each time,5 times/week).Results The therapy plans demonstrated excellent target coverage with low dose on key organs.The treating time was less 15min.Four patients were followed-up,the median duration of follow-up was 9 months(4-15 months),and no recurrence occurred.The side effects included marrow suppression and digestive reaction with good tolerance.Conclusion Tomotherapy shows good efficacy and excellent target coverage on medulloblastoma,and creates a new stage on the treatment of medulloblastoma.更多还原