【摘要】 目的比较氯沙坦与吲达帕胺治疗老年中重度原发性高血压的疗效及安全性。方法氯沙坦组和吲达帕胺组各106例,在硝苯地平控释片基础上分别加用氯沙坦及吲达帕胺,治疗8周,观察治疗前后血压变化及血钾、尿酸变化。结果两组血压每周末与治疗前相比有显著性差异(P<0.05),吲达帕胺组血钾、氯沙坦组及吲达帕胺组血尿酸治疗后较治疗前均有显著性差异(P<0.05),两组间治疗后血尿酸有显著性差异(P<0.01)。结论氯沙坦与吲达帕胺治疗老年中重度原发性高血压均有效,氯沙坦治疗安全可靠,而吲达帕胺治疗降低血钾及升高血尿酸使其在临床应用受到一定的限制。更多还原

【Abstract】 Objective To compare the effects and safety of losartan potassium and indapamide in elderly patients with moderate to severe essential hypertension.Methods Based on the use of nifedipine controlled-release tablets,Losartan Potassium and Indapamide were respectively added to the treatment.212 cases of patients with moderate and severe essential hypertension were divided into Losartan Potassium group and Indapamide group randomly.The course of treatment for both groups lasted for 8 weeks.BP,serum potassium and serum uric acid were measured before and after 8 weeks of treatment.Result After each week’s treatment,BP(P<0.05),serum potassium and uric acid(P<0.01)improved significantly.Conclusion Although both of Losartan Potassium and Inadapamide have effectives on curing moderate and severe essential hypertension,Losartan Potassium is safer and reliable.Certain restrictions should be imposed on the using of Indapamide in the clinical.更多还原