【摘要】 目的了解血液透析患者血清25(OH)D的水平及相关因素。方法选择维持性血液透析治疗>1年、未进行维生素D制剂治疗的患者,对血清25羟维生素D[25(OH)D]、全段甲状旁腺激素(iPTH)、骨特异碱性磷酸酶(BAP)、总钙(矫正钙,Ca)、磷(P)、白蛋白(Alb)及二氧化碳结合力(CO2CP)进行检测及相关分析。结果共入选48例患者,男性30例、女性18例;平均年龄58.7±12.4岁;平均透析龄40.4±50.7个月。25(OH)D的平均水平为41.23±16.41nmol.L-1,低于正常值47.7nmol.L-1的患者占70.8%(34/48)。单因素分析显示,25(OH)D的水平与Alb的水平呈显著的正相关(P<0.05);与年龄、透析龄、iPTH、BAP、Ca、P及CO2CP皆无相关性。结论 25(OH)D在大多数血液透析患者是低下的,与Alb的水平相关;与年龄、iPTH、BAP、Ca及CO2CP无相关性。更多还原

【Abstract】 Objective To evaluate the value of 25(OH)vitaminD[25(OH)D] in hemodialysis patients.Methods 48 cases of maintanance hemodialysis patients who haven’t received therapy of vitamin D(Vit D) were enrolled in this clinical trial.Cross-section analysis of serum 25(OH)D,intact PTH(iPTH),bone specific alkaline phosphatase(BAP),calcium(Ca),phosphorus(P),albumin(Alb)and CO2CP were performed.Results 48 patients including 30 males and 18 females,average age was 58.7±12.4 years,average dialysis treatment period was 40.4±50.7 monthes,the level of 25(OH)D was 41.23±16.41nmol/L,there were 34 cases(70.8% of all patients) whose 25(OH)D level were≤47.7nmol/L.single corralated analysis showed that 25(OH)D was only positive related with Alb(P<0.05);however it had no significant related with age,dialysis time,iPTH,BAP,Ca,P and CO2CP.Conclusion The level of 25(OH)D is rather lower in most hemodialysis patients.It has only significant correlation with Alb,and no correlation with age、iPTH、BAP、Ca及CO2CP.更多还原