【摘要】 目的:探讨原发性高血压患者微量白蛋白尿(MAU)与凝血纤溶指标的关系。方法:入选尿常规蛋白阴性的原发性高血压患者58例及健康对照者18例,分别进行临床和生化指标的检测。结果:根据尿微量白蛋白检测结果,高血压患者分为MAU组27例和NMAU(正常MAU)组31例,MAU组收缩压、舒张压、尿微量白蛋白及凝血纤溶指标中的纤维蛋白原、D-二聚体定量与对照组及NMAU组比较显著性增高(P<0.05)。多元相关分析显示,尿微量白蛋白水平与纤维蛋白原和D-二聚体定量均呈显著性正相关(r=0.613,P<0.01;r=0.842,P<0.01),纤维蛋白原与D-二聚体定量亦呈显著性相关(r=0.694,P<0.01)。结论:纤维蛋白原和D-二聚体定量与高血压患者尿微量白蛋白水平密切相关,提示高血压早期肾损伤时期即存在凝血纤溶指标变化,早期干预凝血纤溶系统的紊乱对减少心血管并发症有一定意义。更多还原

【Abstract】 Objective:To explore the relationship between microalbuminuria changes and blood markers reflecting coagulation and fibrinolysis activities in patients with essential hypertensive.Method:Our study population consisted of 58 cases of essential hypertensive patients with negative regular urinary albumin testing and 18 normal individuals.The clinical and biochemical characteristics were measured.Result:The essential hypertensive patients were divided into 2 groups based on microalbuminuria [microalbuminuria ≥30 mg/L(n=27),normoalbuminuria <30 mg/L(n=31)].Microalbuminuria group had significant higher blood pressure,microalbuminuria,fibrinogen and D-dimer(P<0.05) as compared with normoalbuminuria group and normal control group.Regression analysis showed that microalbuminuria was significantly correlated with fibrinogen and D-dimer(r=0.613,P<0.01;r=0.842,P<0.01),fibrinogen was significantly correlated with D-dimer(r=0.694,P<0.01).Conclusion:Fibrinogen and D-dimer is associated with microalbuminuria in essential hypertensive patients and this suggests there may be some correlation between early renal damage and the changes of coagulative and fibrinolytic system.Thus,earlier intervention of coagulative and fibrinolytic abnormalities in essential hypertensive patients with microalbuminuria may reduce cardiovascular complications.更多还原