【摘要】 目的探讨血清血管内皮生长因子C(vascular endothelial growth factor-C,VEGF-C)水平与膀胱癌发生发展、复发转移和预后的关系。方法选择71例经病理确诊的膀胱癌患者为膀胱癌组,同期健康体检者50例为对照组,采用酶联免疫吸附方法测定两组血清VEGF-C水平并进行比较。结果膀胱癌组血清VEGF-C水平为1.4～42.2μg/L,对照组为0.2～12.6μg/L,差异有统计学意义(P<0.01)。膀胱癌组血清VEGF-C水平与淋巴结转移、淋巴管浸润、血管浸润和复发相关,差异有统计学意义(P<0.05);与临床分期和病理分期无相关性(P>0.05)。血清VEGF-C诊断膀胱癌的灵敏度为81.7%,特异度为72.0%。血清高VEGF-C水平的膀胱癌患者的生存率显著降低,与低VEGF-C水平者比较差异有统计学意义(P<0.05)。结论血清VEGF-C测定可作为膀胱癌早期诊断和判断预后的指标。更多还原

【Abstract】 Objective To explore the relationship between the level of vascular endothelial growth factor-C with the development,recurrence,metastasis and prognosis of bladder cancer.Methods Levels of serum VEGF-C were detected and compared between 71 patients with bladder cancer by pathology diagnosis(bladder cancer group) and 50 healthy controls(control group).Results The serum level of VEGF-C in bladder cancer group(1.4~42.2 μg/L) was significantly higher than that of in control group(0.2~12.6 μg/L)(P<0.01).The serum level of VEGF-C in bladder cancer group was related to lymph nodes metastasis,lymphovascular invasion,vascular infiltrating and recurrence,and the differences were statistically significant(P<0.05);but the serum level was not related to clinical stages and pathological stages(P>0.05).Sensitivity and specificity of serum VEGF-C in diagnosis of bladder cancer were 81.7% and 72.0% respectively.The survival rate in patients with high VEGF-C levels was significantly lower than those with low VEGF-C levels in bladder cancer patients(P<0.05).Conclusion Detection of serum VEGF-C is a useful marker in diagnosis and prognosis of bladder cancer.更多还原