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18F-FDG PET/CT显像对淋巴瘤疗效评价的意义

The Value of 18F-FDG PET/CT in Evaluation of Response to Treatment in Lymphoma

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【作者】 张敬勉赵新明王建方王颖晨张召奇李德志戴春暖

【Author】 ZHANG Jing-mian,ZHAO Xin-ming,WANG Jian-fang,WANG Ying-chen,ZHANG Zhao-qi,LI De-zhi,DAI Chun-nuan(Department of Nuclear Medicine,The 4th Hospital of Hebei Medical University,Shijiazhuang 050011,China)

【机构】 河北医科大学第四医院核医学科及PET/CT中心

【摘要】 目的探讨18氟标记的脱氧葡萄糖(18F-FDG)PET/CT显像对淋巴瘤疗效评价的意义。方法回顾分析我院64例淋巴瘤治疗后18F-FDG PET/CT显像结果,与治疗后单纯CT结果进行对比分析,最终结果经病理和临床随访证实。结果最终共发现病灶219处,其中恶性208处,良性11处。18F-FDG PET/CT评价淋巴瘤治疗效果的灵敏度、特异性、准确性分别为99.52%(207/208)、90.91%(10/11)及99.09%(217/219),均明显优于单纯CT检查(P<0.05)。结论 18F-FDG PET/CT在淋巴瘤疗效评价方面明显优于CT,可为临床选择治疗方案提供早期客观的科学依据,是淋巴瘤疗效监测的有效手段。

【Abstract】 Objective To evaluate the value of 18F-fluorodeoxyglucose(FDG) PET/CT imaging in evaluation of response to treatment in lymphoma.Methods Sixty-four post-treatment patients with lymphoma were studied retrospectively.PET/CT images after therapy were compared with CT posttherapy results.The final diagnosis was based on pathology or clinical follow-ups.Results A total of 208 malignant lesions and 11 benign lesions were found in 64 patients in the study.The sensitivity,specificity and accuracy of 18F-FDG PET/CT were 99.52%(207/208),90.91%(10/11) and 99.09%(217/219),respectively.The difference was significant between PET/CT image and CT alone in sensitivity,specificity and accuracy(P<0.05).Conclusion 18F-FDG PET/CT is better than CT images in the evaluation of response to treatment in lymphoma and 18F-FDG PET/CT examination will become one of the effective technizues in the future.

【基金】 河北省普通高等学校强势特色学科肿瘤学组(冀教高2005[52]);河北省卫生厅“医学科学研究重点课题计划”项目(20100437)
  • 【文献出处】 临床误诊误治 ,Clinical Misdiagnosis & Mistherapy , 编辑部邮箱 ,2012年01期
  • 【分类号】R733.1
  • 【被引频次】5
  • 【下载频次】116
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