【摘要】 目的探讨甲状腺功能亢进症(简称甲亢)患者骨密度改变的临床危险因素。方法对200例甲亢患者(甲亢组)及200例健康者(对照组)均采用双能X线骨密度仪测定腰椎和髋部骨密度值,分析甲亢患者骨质疏松的发生率及影响因素。结果甲亢组腰椎1—4、股骨颈骨密度均明显低于对照组(均P<0.05)。甲亢组骨量减少、骨质疏松的发生率分别为52.2%与32.1%,对照组分别为8.5%与3.0%,2组比较差异均有统计学意义(均P<0.01)。线性回归显示:甲亢为骨密度下降或骨质疏松的危险因素(P=0.003,OR=2.01,95%可信区间1.35～3.05)。结论甲亢患者的骨密度明显降低,骨质疏松发病率明显增高,甲亢为其危险因素。更多还原

【Abstract】 Objective To investigate the risk factors affecting bone mineral density(BMD) in patients with hyperthyroidism.Methods The hip and lumbar spine BMD was measured by dual-energy X-rays absorptiometry(DEXA)in 200 hyperthyroidism patients(hyperthyroidism group) and 200 healthy subjects(control group).The incidence of osteoporosis and the related risk factors were analyzed in patients with hyperthyroidism.Results The hyperthyroidism resulted in significantly lower L1-4 and femoral neck BMD than healthy subjects(P<0.05).Furthermore,hyperthyroidism patients had a higher incidence of osteopenia and osteoporosis(52.2% and 32.1%,respectively) than healthy subjects(8.5% and 3.0%,respectively)(all P<0.01).Linear regression analysis showed that the hyperthyroidism was a risk factor for decreased BMD or osteoporosis(P=0.003,OR=2.01,95% confidence interval: 1.35-3.05).Conclusion The BMD obviously decrease and the incidence of osteoporosis significantly increase in patients with hyperthyroidism.The hyperthyroidism is a risk factor for decreased BMD.更多还原