【摘要】 目的:探讨奥氮平与利培酮治疗首发精神分裂症的疗效以及对生活质量的影响。方法:68例首发精神分裂症患者随机分为奥氮平组和利培酮组各34例,分别给予奥氮平和利培酮治疗8周,随访6个月。于治疗前后采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评定疗效及不良反应;于治疗6个月前后,采用生活质量综合评定问卷(GQOLI)评定生活质量。结果:两组PANSS评分治疗后均有显著下降(P<0.05或P<0.01)。奥氮平组GQOLI总分及各维度与利培酮组GQOLI总分及躯体功能、心理功能维度治疗前后差异均有统计学意义(P均<0.01);两组间比较,治疗前两组GQOLI评分差异无统计学意义,6个月后随访,在躯体功能及社会功能差异有统计学意义(P均<0.01)。结论:奥氮平与利培酮治疗首发精神分裂症疗效相当,但奥氮平在提高生活质量方面略优于利培酮。更多还原

【Abstract】 Objective:To study the curative powers and effect of olanzapine and risperidone on quality of life in the treatment of first onset schizophrenia patients.Method:68 first onset schizophrenia patients were randomly divided into olanzapine group and risperidone group,each of which(n=34) received the olanzapine or risperidone treatment respectively for 8 weeks and 6 months follow-up.The efficacy was assessed using positive and negative syndrome scales(PANSS),and the adverse reaction using treatment emergent symptom scale(TESS).Generic quality of life inventory(GQOLI) was conducted before and 6 months after the treatment for assessmet of patients’quality of life.Results:PANSS score of two groups decreased singnificanty after the treatment(P<0.05 or P<0.01).The significant differences were found on GQOLI total score and each dimension score in olanzeoine group and GQOLI total score,physical function,psychological function in risperidone group between before and after treatment(all P<0.01).After 6 months of follow-up,the two groups showed significant difference on the physical function and social function(all P<0.01),while no significant difference before the treatment.Conclusion:Olanzapine and risperidone are effective and safe in the treatment of first onset schizophrenia patients,and olanzapine may be slightly superior to risperidone in improvement of quality of life.更多还原