【摘要】 目的:探讨环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)在鼻咽癌组织中的表达及其相关性。方法:用免疫组织化学SP法检测58例鼻咽癌患者(鼻咽癌组)和38例鼻咽炎症患者(对照组)黏膜组织中COX-2、VEGF的表达。结果:COX-2、VEGF在鼻咽癌组中的表达均明显高于对照组(均P<0.05)。COX-2、VEGF的表达与鼻咽癌TNM分期有关,Ⅲ～Ⅳ期明显高于Ⅰ～Ⅱ期(P<0.05);与鼻咽癌的浸润和转移有关,有颈淋巴结转移者的表达率明显高于无颈淋巴结转移者(P<0.05)。鼻咽癌组织中COX-2、VEGF的表达呈正相关(r=0.302,P<0.05)。结论:COX-2、VEGF在鼻咽癌发生、发展中起重要作用,在鼻咽癌淋巴结转移中可能有协同效应。更多还原

【Abstract】 Objective:To evaluate the Expression and correlation of cyclooxygenase-2(COX-2) and vascular endothelial growth factor receptor(VEGF) in nasopharyngeal carcinoma.Method:In this study,expression levels of COX-2,VEGF were examined in 58 patients with nasopharyngeal carcinoma and 38 patients with inflammation in nasopharyngeal mucosa by immunohistochemistry method.Result:The expression of COX-2,VEGF were higher in nasopharyngeal carcinoma than those in nasopharyngeal mucosa(P<0.05),and they had some correlation with the invasion and lymphatic metastasis and with the clinical stage of nasopharyngeal carcinoma(P<0.05).The expression of COX-2 was positively correlated with that of VEGF(P<0.05).Conclusion:Thecoexpression of COX-2 and VEGF may play animportant role in the carcinogenesis and development of nasopharyngeal carcinoma,and they may promote lymph node metastasis of nasopharyngeal carcinoma.更多还原