【摘要】 目的探讨高频振荡通气(HFOV)治疗新生儿呼吸衰竭的疗效。方法采用HFOV结合肺复张策略,实现经皮氧饱和度≥0.9。结果 20例患儿在施行HFOV治疗48h后,吸入氧体积分数由(0.72±0.17)降至(0.37±0.17),差异有统计学意义(H=17.820,P<0.05);氧合指数(OI)由(11.94±4.50)降至(2.73±2.24),差异有统计学意义(F=9.662,P<0.05);振荡压力幅度由(31.67±5.92)cmH2O逐渐降至(22.00±5.66)cmH2O,差异有统计学意义(F=3.954,P<0.05);平均气道压由(10.44±1.88)cmH2O降至(8.75±1.39)cmH2O,但差异无统计学意义(F=1.030,P>0.05)。治疗过程中,患儿的心率、血压无明显变化。结论 HFOV治疗新生儿呼吸衰竭安全有效。更多还原

【Abstract】 Objective To evaluate the effectiveness of high frequency oscillatory ventilation(HFOV) in the treatment of respiratory failure in neonates.Methods Twenty neonates with respiratory failure were managed with HFOV.The lung volume recruitment was performed by increasing the mean airway pressure and lung volume to achieve the arterial oxygen saturation ≥0.9.The heart rate,arterial blood pressure,arterial blood gas and oxygenation index were monitored during the course of the high-frequency protocol.Results During 48 hours after initiating HFOV,the FiO2 decreased from(0.72±0.17) to(0.37±0.17)(F=5.204,P<0.05);the oxygenation index decreased from(11.94±4.50) to(2.73±2.24)(F=9.662,P<0.05);the median amplitude pressure decreased from(31.67±5.916) cmH2O to(22.00±5.66) cmH2O(F=3.954,P<0.05);the mean airway pressure decreased from(10.44±1.88) cmH2O to(8.75±1.39) cmH2O(F=1.030,P>0.05).No significant cardiac complication was observed.Conclusion HFOV is safe and effective in treatment of respiratory failure in neonates.更多还原