【摘要】 目的探讨细胞因子IL-6、IL-10、TNF-α在肺炎支原体肺炎(MPP)患儿急性期支气管肺泡灌洗液(BALF)和血清中的变化及临床意义。方法采用双抗体夹心ELISA法对30例MPP患儿急性期和20例无肺部病变的对照组患儿BALF和血清中IL-6、IL-10、TNF-α水平进行测定。结果 MPP患儿BALF和血清中IL-6、IL-10、TNF-α水平在发病的急性期明显高于对照组(P均<0.05),并且BALF中IL-6、IL-10、TNF-α浓度高于血清中相应细胞因子浓度(P均<0.05),血清IL-6、IL-10、TNF-α与相应的BALF中IL-6、IL-10、TNF-α有相关性(r=0.953～0.992,P均<0.05)。结论 MPP患儿BALF和血清中有明显的细胞因子变化,IL-6、IL-10、TNF-α可能参与了MPP的发病。更多还原

【Abstract】 Objective To investigate the changes of cytokines interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)in bronchoalveolar lavage fluid(BALF)and serum in children in acute phase of Mycoplasma pneumoniae pneumonia(MPP).Methods The BALF and serum levels of IL-6,IL-10 and TNF-α were measured using ELISA method in children in acute phase of MMP and in children with no lung infections.Results In 30 children in acute phase of MPP,the levels of IL-6,IL-10 and TNF-α in BALF and serum were significantly higher than those in 20 children with no lung infections(P < 0.05).The levels of IL-6,IL-10 and TNF-α in BALF were all significantly higher than those in serum(P < 0.05).The levels of IL-6,IL-10 and TNF-α in BALF were significantly correlated with those in serum respectively(r = 0.953-0.992,P < 0.05).Conclusions Both of BALF and serum levels of IL-6,IL-10,and TNF-α were significant changed in children in acute phase of MPP.IL-6,IL-10 and TNF-α may be involved in the pathogenesis of MPP.更多还原