【摘要】 目的:研究独活寄生合剂对佐剂性关节炎大鼠模型血清中IL-1β、IL-15及TGF-β1表达水平的影响,探讨独活寄生合剂对佐剂性关节炎的治疗作用及相关机制。方法:雌性大鼠40只,随机分为正常对照组、佐剂性关节炎模型组、独活寄生汤治疗组、强的松治疗组,每组10只,2周后,处死全部大鼠,断头取血,检测血清中IL-1β、IL-15及TGF-β1表达水平。结果:模型组与正常组比较,血清IL-1β、IL-15水平升高,TGF-β1水平降低,治疗组与模型组比较血清IL-1β、IL-15表达水平明显降低,TGF-β1表达水平上调。结论:独活寄生合剂降低佐剂性关节炎大鼠血清IL-1β、IL-15的表达,上调TGF-β1的表达水平,对类风湿性关节炎的治疗有一定意义。更多还原

【Abstract】 Objective: To study the effects of Dohuo Jisheng Heji on serum IL-1β、IL-15 and TGF-β1 in adjuvant arthritis rats,and explore the treatment functions on adjuvant arthritis and related mechanisms.Methods: 40 rats were randomized into 4 groups: normal control rats,adjuvant arthritis rats,adjuvant arthritis rats treated with Dohuo Jisheng Heji,and adjuvant arthritis rats treated with Prednisone(N=10).the expression levels of IL-1β、IL-15、TGF-β1 in serum were detected after 2 weeks of treatment.Results: IL-1β、IL-15 level was higher and TGF-β1 level was lower in adjuvant arthritis rats than those in normal control rats(P<0.05).The expression level of IL-1β、IL-15 in the Dohuo Jisheng Heji-treated group was significantly lower than those in adjuvant arthritis rats,but the expression levels of TGF-β1 were increased(P<0.05).Conclusion: Dohuo Jisheng Heji therapy down-regulate the expression level of IL-1β、IL-15 and up-regulate the level of TGF-β1.It has certain significance in the treatment of rheumatoid arthritis.更多还原