【摘要】 目的:通过比较本地区健康人与癫痫患者CYP2D6*10基因多态性的差异,探索CYP2D6*10基因多态性与癫痫易感的关系。方法:应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测健康人和癫痫患者CYP2D6*10的基因型分布及等位基因频率,通过χ2检验来比较健康人和癫痫患者的基因型分布差异和等位基因频率差异。结果:健康人和癫痫患者的基因型分布及等位基因频率差异有显著性和高度显著性(P<0.05和P<0.01)。结论:癫痫病的发生与CYP2D6*10的碱基变异具有相关性。更多还原

【Abstract】 Objective:To explore the relationship between CYP2D6*10 gene polymorphisms and the Epilepsy pathogenesis,by comparing the differences of CYP2D6*10 Gene polymorphisms in healthy populations and patients with epilepsy in the region.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was applied to detect the genotype distribution and the allele frequencies of CYP2D6*10 in healthy populations and patients with epilepsy,and to compare their differences between them according to Chi-square criterion.Results:There exist significant differences in the genotype distribution and allele frequencies of CYP2D6*10 in healthy populations and patients with epilepsy(P<0.05,P<0.01).Conclusion:The epilepsy pathogenesis is related with the base variations of CYP2D6*10.更多还原