【摘要】 目的:研究肿瘤耐药相关基因P-糖蛋白(P-gp)和三磷酸腺苷结合转运蛋白G超家族成员(ABCG2)在口腔鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法:应用免疫组化Envision法检测口腔鳞状细胞癌组织76例及正常黏膜组织30例,观察肿瘤耐药相关基因P-gp和ABCG2的表达,同时回顾性研究了这些表达与口腔鳞状细胞癌发生、浸润及转移等临床病理学参数的关系。结果:口腔鳞状细胞癌组织中,P-gp和AB-CG2的表达阳性率分别为88.16%和80.26%。30例正常黏膜组织中,两者的表达率分别为60%和50%,差异有统计学意义(P<0.05)。口腔鳞状细胞癌组织中,P-gp在不同临床分期、不同浸润深度组之间阳性表达率的差异有统计学意义(P<0.05)。ABCG2在不同临床分期、有或无淋巴结转移组之间阳性表达率的差异有统计学意义(P<0.05)。P-gp与ABCG2的表达呈正相关r=0.228(P<0.05)。结论:P-gp和ABCG2在口腔鳞癌的发生发展中可能有协同作用。检测P-gp和ABCG2的表达对口腔鳞癌化疗方案的制定、判断预后有重要指导意义。更多还原

【Abstract】 Objective: To investigate clinical pathology significance and expression of P-gp and ABCG2 in oral squamous cell carcinoma.Methods: Envision immunohistochemical method was used to detect the expressions of P-gp and ABCG2 in 76 cases of oral squamous cell carcinoma and in 30 cases of normal tissues,and to analyse the relationship between them and different clinical pathological factors.Results: The positive frequency of P-gp and ABCG2 in oral carcinoma tissues is 88.16% and 80.26%,and in normal tissues is 60% and 50%.The difference was statistically significant(P<0.05).In different clinical stages and different depth of invasion of oral carcinoma the positive frequency of P-gp protein was statistically significant(P<0.05).In different clinical stages and with or without lymph node metastasis of oral carcinoma the positive frequency of ABCG2 protein was statistically significant(P<0.05).The expression of P-gp was positively correlated with ABCG2(r=0.228,P<0.05).Conclusion: It is possibly that P-gp in coordination with ABCG2 in the pathogenesis of oral squamous cell carcinoma.更多还原