【摘要】 血管紧张素转化酶是一种可以催化血管紧张素Ⅰ转化为血管紧张素Ⅱ的蛋白酶。血管紧张素Ⅱ拥有比血管紧张素Ⅰ更强的活性,能使全身小动脉收缩进而升高血压,同时还具有刺激肾上腺皮质分泌醛固酮的作用,醛固酮具有保钠、保水、排钾的功能,能影响体液的水-电解质平衡而对机体带来广泛的影响。血管紧张素转化酶还能作用于激肽释放酶-激肽系统,通过灭活缓激肽而使血管收缩,并使血管通透性下降、血管对刺激的反应增强。近年来的一些研究表明血管紧张素转化酶的多态性与脑血管病的发生密切相关,文章旨在对近年来这方面的相关文献做一综述。更多还原

【Abstract】 Angiotensin converting enzyme(ACE) gene encodes an enzyme involved in catalyzing the conversion of angiotensin Ⅰ(AngⅠ) into a physiologically active peptide angiotensin Ⅱ(AngⅡ).AngⅡ is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance,at the same time ACE can function in the kallikrein-kinin system through inactivation of bradykinin to cause vasoconstriction,vascular permeability decrease and vascular response to stimulus enhancement.Recent studies have shown that the ACE gene polymorphism is closely related to cerebrovascular disease.This article will review some recent literatures on ACE gene polymorphism and its relevance to the cerebrovascular disease.更多还原