【摘要】 目的明确福建地区无症状女性人群宫颈人乳头瘤状病毒(HPV)的感染现状,指导相关预防性疫苗的接种。方法采用流式荧光杂交法对2011年3月至2012年3月采集的3 052例健康体检女性人群宫颈脱落细胞样本进行分型检测。结果总HPV感染率为11.3%,高危型HPV感染率为10.4%,感染前5位的型别分别为HPV-52(2.3%),HPV-58(1.7%),HPV-16(1.6%),HPV-18(0.8%),HPV-68(0.7%)。HPV感染年龄分布存在双峰现象,20～24岁年龄组的HPV-16感染率明显较高。结论福建地区无症状女性人群中,HPV-52及HPV-58的感染率相对较高,提示包含HPV-52及HPV-58的第2代预防性疫苗能为福建地区女性提供更好的保护。HPV感染存在2个年龄高峰,对疫苗的适用具有指导意义。对有性生活的年轻女性进行普遍的包含HPV-16的预防性疫苗的补救性接种会获得较大收益。更多还原

【Abstract】 Objective To clear Fujian region in asymptomatic women with cervical human papillomavirus virus(HPV) infection status for guidance to the relevant preventive vaccines targeted.Methods 3 052 healthy women cervical exfoliated cell samples were detected by flow fluorescence hybridization methods from March 2011 to March 2012.Results The total rate of HPV infection was 11.3%,high-risk HPV infection rate was 10.4%,the infection ranked top five types were HPV-52(2.3%),HPV-58(1.7%),HPV-16(1.6%),HPV-18(0.8%),HPV-68(0.7%) respectively.HPV infection age distribution was the presence of Shuangfeng phenomenon.20-24 years old age group,HPV-16 infection rate increased significantly.Conclusion Fujian region in asymptomatic female popuLation,HPV-52and HPV-58 infection rates are relatively high,suggests than the second generation of prophylactic vaccines contains HPV-52and HPV-58 have higher probability of protection for women in Fujian area.Fujian region in asymptomatic female population,HPV infection has presence of two age peaks,this vaccine has guiding significance to apply.It can gain bigger profit to launch preventive vaccine remedial inoculation which contains HPV-16 for sexual life of young women.更多还原