【摘要】 目的探讨蛛网膜下腔出血(SAH)性脑血管痉挛(CVS)与血管壁病理学改变之间的因果关系。方法采用药理学预阻滞法,通过光镜和电镜对42只猫SAH后CVS的形成及其对血管壁病理性改变的影响作用进行观察。结果预先使用血管外周阻滞剂可以明显地减轻SAH所致的CVS反应程度,并使血管壁发生的病理性改变也随之减轻。结论 CVS是血管壁发生病理性改变的成因,继而又成为影响SAH预后的主要原因之一。预防或阻止CVS的发生,可有效地防止血管壁发生相应的病理学改变。更多还原

【Abstract】 Objective To evaluate the relation between cerebral vasospasm(CVS) following subarachnoid hemorrhage(SAH) and pathological changes in vessel wall.Methods The emergence and effect of cerebral vasospasm(CVS) following SAH to pathological changes in vessel wall in 42 cats were observed by pharmacological block method with photo-electronic microscopy.Results Prophylactic use of paravasospam antagonist may reduce obviously reacting extent of CVS following SAH and the pathological changes of the wall.Conclusion CVS is one of main causes of the pathological changes that affects prognosis of SAH.Effectively to prevent and block CVS would prevent effectively the pathological changes of the wall.更多还原