【摘要】 目的:分析150例原发性IgAN的临床和病理特点,为治疗和预后判断提供依据。方法:对150例原发性IgAN患者的临床和病理特点进行相关性及回归分析。结果:(1)150例患者中有血尿者114例,其中男44例,女70例,女性患者明显多于男性患者(P<0.01);有44例患者发生肉眼血尿,其中24例肉眼血尿与急性扁桃体炎有关。(2)临床特点与病理分级相关性分析结果显示,肾脏病理Lee氏高分级与高血压有相关关系(r=0.557,P=0.000),肾功能损害与肾脏病理Lee氏高分级有相关关系(r=0.678,P=0.000),肾脏病理Lee氏高分级与蛋白尿有相关关系(r=0.588,P=0.001),各病理分级间血尿发生率差异无统计学意义(P>0.05)。(3)回归分析显示肾脏病理Lee分级(P=0.000)和高血压(P=0.001)分别是患者肾功能损害的两个独立危险因素。结论:在本研究中,女性患者血尿发生率高;肉眼血尿发生的诱因以急性扁桃体炎最为常见。蛋白尿的程度、高血压、肾功能损害均与肾脏病理Lee氏分级呈正相关。肾脏病理Lee分级和高血压是本组患者肾功能损害的独立危险因素。更多还原

【Abstract】 Objective:To analysis the clinical and pathologic Features of 150 cases of primary IgA nephropathy(IgAN) and try to provide helpful information in treatment and prognosis of IgAN.Methods:The clinical and pathological data of 150 cases of primary IgAN,confirmed by renal biopsy from January 2006 to December 2007 in Shenzheng 2nd people’s hospital,were retrospectively analyzed.Results:(1) Hematuria was found in 114(76%) cases of the analysis group which included 44 males and 70 females,Macroscopic hematuria was found in 44(29.3%) cases,in which 24 cases were acute tonsillitis related.(2) Analysis of pathological and clinical data revealed that Hypertension showed a positive corelation with the Lee’s grade(r = 0.557,P < 0.000).Impaired renal function had a positive corelation with the Lee’s grade(r = 0.678,P < 0.000).The Lee’s grade has a positive corelation with the incidence of proteinuria(r = 0.588,P < 0.05).There was no significant difference among different Lee’s grades in hematuria cases(P >0.05).(3) logistic regression equation revealed that Lee’s grade(P =0.000) and hypertension(P =0.001) were independent risk factors of impaired renal.Conclusion:In this group of primary IgAN cases,occurrence of hematuria was significantly higher in females than in males.The most frequent incentive factor of macroscopic hematuria was acute tonsillitis.the quantitation of urine protein output and hypertension and abnormal renal function all have positive corelation with Lee’s grade.In this group of primary IgAN cases,Lee’s grade and hypertension were independent risk factors for patients with impaired renal function.更多还原