【摘要】 目的探讨肾脏疾病患儿中血清胱抑素C及血清肌酐、血清尿素氮、血清β2微球蛋白检测的临床意义。方法采用微粒子增强比浊法测试胱抑素C。同时检测血肌酐(Cr)、内生肌酐清除率(CCr、血清尿素氮(BUN)、血清β2微球蛋白(β2-MG)。结果各组肾功能指标皆不同程度高于正常对照组,肾功能正常组Cr、BUN、CCr与对照组比较无显著性差异(P>0.05)。Cys C、β2-MG与对照组比较有显著性差异(P<0.05)。Cys C与Cr、BUN、β2-MG呈高度正相关,与CCr呈高度负相关。结论胱抑素C是反映小儿肾小球滤过率的重要指标,是肾功能损害早期的敏感指标。在儿童肾病的早期诊断中具有指导意义。更多还原

【Abstract】 Objective To explore the clinical significance of serum concentrations of Cystatin C(Cys C),urea nitrogen(BUN),creatinine(Cr) and β2 microglobulin(β2-MG) in children kidney disease.Methods The corpuscle enhanced immunoturbidimetric method was adopted to detect the concentration of serum Cys C.On the other hand,BUN,Cr,β2-MG,and creatinine clearance rate(CCr) were detected too.Results The indicators of kidney disease are all higher than those of the control group.The concentrations of Cys C and β2-MG in normal kidney function group were statistically different from the control group(P<0.05),while the BUN,Cr and CCr values had no statistical difference between the two groups(P>0.05).In addition,the Cys C concentration was highly positively correlated with BUN,Cr,β2-MG concentrations,and highly negatively correlated with the CCr value.Conclusion The serum Cys C is an important indicator of glomerular filtration rate(GFR),and is a sensitive indicator of early impairment of renal function.The serum concentration of Cys C is essential for early diagnosis of children kidney diseases.更多还原