【摘要】 目的研究大豆苷元(daidzein,DD)对压力负荷性大鼠一氧化氮(NO)、血管紧张素Ⅱ(AngⅡ)的影响。方法采用腹主动脉缩窄术制备大鼠实验模型。将大鼠随机分为假手术对照组、模型组、DD(30、60、120 mg.kg-1)治疗组。给药4周后处死大鼠,检测大鼠主动脉、心肌组织及肾组织NO含量;血浆、心肌组织及肾组织AngⅡ含量。结果与模型组比较,DD能使大鼠主动脉、心肌组织、肾组织NO含量显著升高;血浆、心肌组织、肾组织AngⅡ含量显著降低。结论 DD可以升高压力负荷性大鼠NO含量、抑制AngⅡ产生。更多还原

【Abstract】 Objective To study the influence of daidzein on nitrogen oxide(NO) and angiotensinⅡ(AngⅡ) in rats induced by pressure overload.Methods The model rats were prepared by abdominal aorta constriction.The operated rats were divided into sham operated control group,aorta-constricted model group and three DD-treated groups(30,60,120 mg·kg-1).After four weeks treatment,the contents of NO in aorta,myocardium and nephridial tissue and the contents of AngⅡ in plasma,myocardium and nephridial tissue of all rats were measured.Results In comparison with aorta-constricted model group,DD could significantly increase the contents of NO in aorta,myocardium and nephridial tissue and decrease the contents of AngⅡ in plasma,myocardium and nephridial tissue.Conclusion DD can increase the contents of NO and decrease the contents of AngⅡin rats induced by pressure overload.更多还原